Viral Loads in Skin Samples of Patients with Monkeypox Virus Infection: A Systematic Review and Meta-Analysis.
Isha RaniPrakasini SatapathyAnmol GoyalMuhammad Aaqib ShamimAmit PalRosanna SquittiKalyan GoswamiKeerti Bhusan PradhanSarvesh RustagiAlaa Hamza HermisJoshuan J BarbozaAlfonso Javier Rodriguez-MoralesRanjit SahBijaya Kumar PadhiPublished in: Viruses (2023)
Despite monkeypox (mpox) being a public health emergency, there is limited knowledge about the risk of infectivity from skin viral loads during mpox infection. Thus, the aim of this study was to estimate cutaneous viral loads among mpox patients globally. Several databases, including Cochrane, EBSCOHost, EMBASE, ProQuest, PubMed, Scopus, and Web of Science, and preprint servers were searched concerning skin mpox viral loads in confirmed mpox subjects. In this systematic review and meta-analysis, a total of 331 articles were initially screened after the removal of duplicate entries. A total of nine articles were included in the systematic review and meta-analysis for the overall estimation of viral loads (Ct) using a random-effect model. The pooled cutaneous mpox viral load (lower Ct) was 21.71 (95% CI: 20.68-22.75) with a majority of positivity rates being 100%, highlighting a higher infectivity risk from skin lesions. The current results strongly support that skin mpox viral loads may be a dominant source of rapid transmission during current multi-national outbreaks. This important finding can help in constructing useful measures in relevant health policy.
Keyphrases
- public health
- sars cov
- healthcare
- soft tissue
- wound healing
- end stage renal disease
- computed tomography
- mental health
- chronic kidney disease
- ejection fraction
- emergency department
- randomized controlled trial
- image quality
- prognostic factors
- machine learning
- global health
- deep learning
- health information
- quality improvement
- big data
- infectious diseases
- loop mediated isothermal amplification