DNA methylation and repressive H3K9 and H3K27 trimethylation in the promoter regions of PD-1, CTLA-4, TIM-3, LAG-3, TIGIT, and PD-L1 genes in human primary breast cancer.

Varun Sasidharan NairHaytham El SalhatRowaida Z TahaAnne JohnBassam R AliEyad Elkord

Published in: Clinical epigenetics (2018)

Our data demonstrate that both DNA and histone modifications are involved in upregulation of PD-1, CTLA-4, TIM-3, and LAG-3 in breast tumor tissue and these epigenetic modifications could be useful as diagnostic/prognostic biomarkers and/or therapeutic targets in breast cancer.

Keyphrases

dna methylation
genome wide
gene expression
endothelial cells
cell proliferation
copy number
electronic health record
poor prognosis
big data
induced pluripotent stem cells
cell free
signaling pathway
transcription factor
pluripotent stem cells
young adults
breast cancer risk
long non coding rna
nucleic acid