Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy.
Yang ZhaoZiyi ChangGuizhen ZhaoHaocheng LuWenhao XiongWenying LiangHuilun WangLuis VillacortaMinerva T Garcia-BarrioTianqing ZhuYanhong GuoYanbo FanLin ChangFrancisco J SchopferBruce A FreemanJifeng ZhangY Eugene ChenPublished in: Cardiovascular drugs and therapy (2020)
Administration of NO2-OA protects against AAA formation and multifactorial macrophage activation. With NO2-OA currently undergoing FDA approved phase II clinical trials, these findings may expedite the use of this nitro-fatty acid for AAA therapy.