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Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy.

Yang ZhaoZiyi ChangGuizhen ZhaoHaocheng LuWenhao XiongWenying LiangHuilun WangLuis VillacortaMinerva T Garcia-BarrioTianqing ZhuYanhong GuoYanbo FanLin ChangFrancisco J SchopferBruce A FreemanJifeng ZhangY Eugene Chen
Published in: Cardiovascular drugs and therapy (2020)
Administration of NO2-OA protects against AAA formation and multifactorial macrophage activation. With NO2-OA currently undergoing FDA approved phase II clinical trials, these findings may expedite the use of this nitro-fatty acid for AAA therapy.
Keyphrases
  • phase ii
  • clinical trial
  • abdominal aortic aneurysm
  • fatty acid
  • open label
  • adipose tissue
  • knee osteoarthritis
  • stem cells
  • phase iii
  • randomized controlled trial
  • double blind
  • mesenchymal stem cells
  • drug administration