The Effectiveness of 23-valent Pneumococcal Polysaccharide Vaccine on Elderly Colorectal Cancer Long-Term Survivors: A population-based exact-matched cohort study.
Moon-Sing LeeShin-Yi ChiouFeng-Chun HsuHon-Yi LinChung-Yi LiShih-Kai HungBen-Hui YuChin-Chia WuLiang-Cheng ChenChia-Hui ChewWen-Yen ChiouPublished in: Human vaccines & immunotherapeutics (2024)
Colorectal cancer (CRC) long-term survivor is a rapid enlarging group. However, the effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPSV23) on this group is unknown. This nationwide population-based study in Taiwan was designed to examine the effect of PPSV23 on incidence rate ratio (IRR) of pneumonia hospitalization, cumulative incidence, and overall survival rate for these long-term CRC survivors. This cohort study was based on the Taiwan Cancer Registry and Taiwan National Health Insurance Research Database from 2000-2017. After individual exact matching to covariates with 1:1 ratio, there were a total of 1,355 vaccinated and 1,355 unvaccinated survivors. After adjusted by multivariate Poisson regression model, vaccinated group had a non-significantly lower pneumonia hospitalization risk than unvaccinated, with an adjusted IRR of 0.879 ( p = .391). Besides, vaccinated group had both lower cumulative incidence rate and higher overall survival time than unvaccinated.
Keyphrases
- health insurance
- risk factors
- young adults
- randomized controlled trial
- systematic review
- papillary thyroid
- healthcare
- free survival
- squamous cell carcinoma
- cross sectional
- emergency department
- intensive care unit
- middle aged
- squamous cell
- respiratory failure
- childhood cancer
- lymph node metastasis
- loop mediated isothermal amplification
- molecular dynamics