COVID-19: The question of genetic diversity and therapeutic intervention approaches.
David Livingstone Alves FigueiredoJoão Paulo Bianchi XimenezFábio Rodrigues Ferreira SeivaCarolina PanisRafael Dos Santos BezerraAdriano FerrasaAlessandra Lourenço CecchiniAlexandra Ivo de MedeirosAna Marisa Fusco AlmeidaAnelisa RamãoAngelica Beate Winter BoldtCarla Fredrichsen MoyaChung Man ChinDaniel de PaulaDaniel RechDaniela Fiori GradiaDanielle MalheirosDanielle VenturiniEliandro Reis TavaresEmerson CarraroEnilze Maria de Souza Fonseca RibeiroEvani Marques PereiraFelipe Francisco TuonFranciele Aní Caovilla FolladorGlaura Scantamburlo Alves FernandesHélito VolpatoIlce Mara de Syllos CólusJaqueline Carvalho de OliveiraJean Henrique da Silva RodriguesJean Leandro Dos SantosJeane Eliete Laguila VisentainerJuliana Cristina BrandiJuliana Mara SerpeloniJuliana Sartori BoniniKaren Brajão de OliveiraKarine FiorentinLéia Carolina LucioLigia Carla Faccin-GalhardiLirane Elize Defante FerretoLucy Megumi Yamauchi LioniMarcia Edilaine Lopes ConsolaroMarcelo Ricardo VicariMarcos Abdo ArbexMarcos PileggiMaria Angelica Ehara WatanabeMaria Antônia Ramos CostaMaria José S Mendes GianniniMarla Karine AmaranteNajeh Maissar KhalilQuirino Alves de Lima NetoRoberto H HeraiRoberta Losi GuembarovskiRogério N ShinsatoRubiana Mara MainardesSilvana GiuliattiSueli Fumie Yamada-OgattaViviane Knuppel de Quadros GerberWander Rogério PavanelliWeber Claudio da SilvaMaria Luiza Petzl-ErlerValeria ValenteChristiane Pienna SoaresLuciane Regina CavalliWilson Araújo da Silva JuniorPublished in: Genetics and molecular biology (2022)
Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The disease, which emerged in China's Wuhan province, had its first reported case on December 29, 2019, and spread rapidly worldwide. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic and global health emergency. Since the outbreak, efforts to develop COVID-19 vaccines, engineer new drugs, and evaluate existing ones for drug repurposing have been intensively undertaken to find ways to control this pandemic. COVID-19 therapeutic strategies aim to impair molecular pathways involved in the virus entrance and replication or interfere in the patients' overreaction and immunopathology. Moreover, nanotechnology could be an approach to boost the activity of new drugs. Several COVID-19 vaccine candidates have received emergency-use or full authorization in one or more countries, and others are being developed and tested. This review assesses the different strategies currently proposed to control COVID-19 and the issues or limitations imposed on some approaches by the human and viral genetic variability.
Keyphrases
- coronavirus disease
- sars cov
- respiratory syndrome coronavirus
- public health
- emergency department
- global health
- end stage renal disease
- genetic diversity
- healthcare
- randomized controlled trial
- chronic kidney disease
- type diabetes
- endothelial cells
- ejection fraction
- cardiovascular events
- peritoneal dialysis
- south africa
- coronary artery disease
- newly diagnosed
- single molecule
- genome wide