Integrative transcriptome-wide analysis of atopic dermatitis for drug repositioning.
Jaeseung SongDaeun KimSora LeeJunghyun JungJong Wha J JooWonhee JangPublished in: Communications biology (2022)
Atopic dermatitis (AD) is one of the most common inflammatory skin diseases, which significantly impact the quality of life. Transcriptome-wide association study (TWAS) was conducted to estimate both transcriptomic and genomic features of AD and detected significant associations between 31 expression quantitative loci and 25 genes. Our results replicated well-known genetic markers for AD, as well as 4 novel associated genes. Next, transcriptome meta-analysis was conducted with 5 studies retrieved from public databases and identified 5 additional novel susceptibility genes for AD. Applying the connectivity map to the results from TWAS and meta-analysis, robustly enriched perturbations were identified and their chemical or functional properties were analyzed. Here, we report the first research on integrative approaches for an AD, combining TWAS and transcriptome meta-analysis. Together, our findings could provide a comprehensive understanding of the pathophysiologic mechanisms of AD and suggest potential drug candidates as alternative treatment options.
Keyphrases
- genome wide
- atopic dermatitis
- systematic review
- rna seq
- dna methylation
- single cell
- copy number
- gene expression
- case control
- meta analyses
- healthcare
- poor prognosis
- randomized controlled trial
- mental health
- emergency department
- multiple sclerosis
- oxidative stress
- resting state
- transcription factor
- machine learning
- binding protein
- artificial intelligence
- high density
- big data
- genome wide association
- genome wide association study