Inhibition of retinal neovascularization by VEGF siRNA delivered via bioreducible lipid-like nanoparticles.

Zonghua WangAnqi LiuHan ZhangMing WangQiao TangYifei HuangLiqiang Wang

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2020)

Our results demonstrate that bioreducible lipidoid nanoparticles conveying VEGF siRNA can effectively inhibit retinal neovascularization in a rodent model of OIR, and reduce the expression of VEGF mRNA and protein. This novel treatment modality could have profound implications for treating retinal angiogenic diseases.

Keyphrases

vascular endothelial growth factor
diabetic retinopathy
optical coherence tomography
endothelial cells
optic nerve
binding protein
poor prognosis
cancer therapy
fatty acid
autism spectrum disorder
small molecule
hyaluronic acid
protein protein
amino acid