Amplifications of AURKA and AURKB in a Burkitt lymphoma immunodeficiency-associated type: a case report.
Fábio Morato de OliveiraVinícius Gonçalves de SouzaAparecida de Lourdes CarvalhoFermino Sanches Lizarte NetoCarla Silva Siqueira MirandaPublished in: Einstein (Sao Paulo, Brazil) (2023)
In equatorial Brazil, the association of Burkitt lymphoma and Epstein-Barr virus manifests at high rates. Here, we report, for the first time, amplifications of aurora kinase genes (AURKA/B) in a patient with a history of periodontal abscess and the presence of a remaining nodule, diagnosed with Burkitt lymphoma and Epstein-Barr virus, and /HIV positive. The patient was a 38-year-old man who presented with a 2-week-old severe jaw pain and a 3-day-old severe bilateral headache. He had a history of human papilloma virus. Interphase FISH analysis showed AURKA and AURKB amplification. The patient's condition worsened, progressing to death a month after the initial care. Changes in the MYCC and AURKA pathways are directly associated with genomic instability. Thus, MYCC rearrangements and higher expression of AURKA/B may be associated with therapy resistance, highlighting the importance of AURKA/B evaluation in Burkitt lymphoma.
Keyphrases
- epstein barr virus
- diffuse large b cell lymphoma
- hiv positive
- case report
- men who have sex with men
- healthcare
- antiretroviral therapy
- chronic pain
- south africa
- poor prognosis
- pain management
- clinical trial
- palliative care
- endothelial cells
- randomized controlled trial
- gene expression
- spinal cord injury
- human immunodeficiency virus
- mesenchymal stem cells
- quality improvement
- tyrosine kinase
- dna methylation
- copy number
- neuropathic pain
- hiv infected
- binding protein
- double blind
- protein kinase
- study protocol
- smoking cessation
- disease virus
- bioinformatics analysis