Experimental Modeling of Necrotizing Enterocolitis in Human Infant Intestinal Enteroids.

Christie BuonpaneGuillermo AresCarrie YuanCamille SchlegelHeather LiebeCatherine J Hunter

Published in: Journal of investigative surgery : the official journal of the Academy of Surgical Research (2020)

We demonstrate that NEC can be induced in premature human enteroids as supported by corresponding alterations in inflammation, apoptosis, tight junction expression, and permeability by treatment with lipopolysaccharide.

Keyphrases

endothelial cells
oxidative stress
high glucose
induced pluripotent stem cells
poor prognosis
pluripotent stem cells
blood brain barrier
diabetic rats
endoplasmic reticulum stress
drug induced
long non coding rna
combination therapy
preterm infants
replacement therapy