Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS).

Puja MehtaRomit J SamantaKatherine WickRebecca C CollThea MawhinneyPatrick G McAleaveyAndrew J BoyleJohn ConlonManu Shankar-HariAngela RogersCarolyn S CalfeeMichael A MatthayCharlotte Summers Rachel Clare ChambersDaniel Francis McAuleyCecilia M O'Kane

Published in: Thorax (2023)

Ferritin is a clinically useful biomarker in ARDS and is associated with worse patient outcomes. These results provide support for prospective interventional trials of immunomodulatory agents targeting IL-18 in this hyperferritinaemic subgroup of patients with ARDS.

Keyphrases

randomized controlled trial
acute respiratory distress syndrome
extracorporeal membrane oxygenation
mechanical ventilation
study protocol
cardiovascular events
risk factors
cancer therapy
type diabetes
cardiovascular disease
coronary artery disease