Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment.
Abinaya ShanmugavadivuSundaravadhanan LekhavadhaniP J MirandaNagarajan SelvamuruganPublished in: Biomedical materials (Bristol, England) (2024)
Osteosarcoma (OS) is a malignant bone neoplasm plagued by poor prognosis. Major treatment strategies include chemotherapy, radiotherapy, and surgery. Chemotherapy to treat OS has severe adverse effects due to systemic toxicity to healthy cells. A possible way to overcome the limitation is to utilize nanotechnology. Nanotherapeutics is an emerging approach in treating OS using nanoparticulate drug delivery systems. Surgical resection of OS leaves a critical bone defect requiring medical intervention. Recently, tissue engineered scaffolds have been reported to provide physical support to bone defects and aid multimodal treatment of OS. These scaffolds loaded with nanoparticulate delivery systems could also actively repress tumor growth and aid new bone formation. The rapid developments in nanotherapeutics and bone tissue engineering have paved the way for improved treatment efficacy for OS-related bone defects. This review focuses on current bifunctional nanomaterials-based tissue engineered (NTE) scaffolds that use novel approaches such as magnetic hyperthermia, photodynamic therapy, photothermal therapy, bioceramic and polymeric nanotherapeutics against OS. With further optimization and screening, NTE scaffolds could meet clinical applications for treating OS patients.
Keyphrases
- tissue engineering
- poor prognosis
- bone mineral density
- photodynamic therapy
- randomized controlled trial
- soft tissue
- drug delivery
- long non coding rna
- end stage renal disease
- chronic kidney disease
- bone regeneration
- bone loss
- physical activity
- healthcare
- induced apoptosis
- newly diagnosed
- mental health
- body composition
- radiation therapy
- coronary artery disease
- radiation induced
- atrial fibrillation
- patient reported outcomes
- early onset
- mass spectrometry
- coronary artery bypass
- wound healing
- endoplasmic reticulum stress
- patient reported
- molecularly imprinted