Nuclear factor erythroid 2-related factor 2 and β-Catenin Coactivation in Hepatocellular Cancer: Biological and Therapeutic Implications.
Junyan TaoYekaterina KrutsenkoAkshata MogheSucha SinghMinakshi PoddarAaron BellMichael OertelAatur D SinghiDavid GellerXin ChenAmaia LujambioSilvia LiuSatdarshan Paul MongaPublished in: Hepatology (Baltimore, Md.) (2021)
Coactivation of β-catenin and Nrf2 is evident in 9% of all human HCCs. Coexpression of mutant NFE2L2 and mutant CTNNB1 led to clinically relevant HCC development in mice, which responded to mTOR inhibitors. Thus, this model has both biological and therapeutic implications.