Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases.

Colin S Wood Kathryn A F Pennel Holly Leslie Assya Legrini Andrew J Cameron Lydia Melissourgou-Syka Jean A Quinn Hester C van Wyk Jennifer Hay Antonia K Roseweir Colin Nixon Campbell Stuart Roxburgh Donald C McMillan Andrew V Biankin Owen James Sansom Paul G Horgan Joanne Edwards Colin W Steele Nigel B Jamieson

Published in: Cancer research (2023)

Spatial transcriptomics uncovers heterogeneity between patients, between matched lesions in the same patient, and within individual lesions and identifies drivers of metastatic progression in colorectal cancer with reactive and suppressed immune microenvironments.

Keyphrases

single cell
liver metastases
newly diagnosed
end stage renal disease
ejection fraction
squamous cell carcinoma
small cell lung cancer
chronic kidney disease
genome wide
case report
gene expression
dna methylation
patient reported