Owen James Sansom (O J Sansom, Owen Sansom, Owen J Sansom)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 117

Top Venues

Nature communications

Oncogene

Nature genetics

Science advances

University of Glasgow

University of Edinburgh (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Glasgow Oct 01 2018

United Kingdom

Director :: Institute of Cancer Sciences

Cancer Research UK Beatson Institute Aug 01 2017

United Kingdom

Director

Cancer Research UK Beatson Institute

United Kingdom

Senior Group Leader

Cancer Research UK Beatson Institute Jun 01 2016 - Jul 31 2017

United Kingdom

Interim Director

Cancer Research UK Beatson Institute Apr 01 2011 - May 31 2016

United Kingdom

Deputy Director

Cancer Research UK Beatson Institute

United Kingdom

Junior Group Leader

University of Cardiff

United Kingdom

Postdoctoral research fellow :: School of Biosciences

Education History

University of Edinburgh

United Kingdom

PHD

Publications

Arafath K Najumudeen, Sigrid K Fey, Laura M Millett, Catriona A Ford, Kathryn Gilroy, Nuray Gunduz, Rachel A Ridgway, Eve Anderson, Douglas Strathdee, William Clark, Colin Nixon, Jennifer P Morton, Andrew D Campbell, Owen James Sansom
KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo. Nature communications 15 (1) (2024)
Rana Fetit, Alistair Stewart McLaren, Mark White, Megan L Mills, John Falconer, Xabier Cortes-Lavaud, Kathryn L Gilroy, Tamsin R M Lannagan, Rachel A Ridgway, Colin Nixon, Varushka Naiker, Renee Njunge, Cassie J Clarke, Declan Whyte, Kristina Kirschner, Rene Jackstadt, James C Norman, Leo M Carlin, Andrew D Campbell, Owen James Sansom, Colin W Steele
Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-specific Neutrophils. Cancer research communications 4 (2) (2024)
Gaurav Malviya, Tamsin R M Lannagan, Emma Johnson, Agata Mackintosh, Robert Bielik, Adam Peters, Dmitry Soloviev, Manikandan Kadirvel, Rene Jackstadt, Colin Nixon, Kathryn L Gilroy, Andrew D Campbell, Owen James Sansom, David Y Lewis
Noninvasive Stratification of Colon Cancer by Multiplex PET Imaging. Clinical cancer research : an official journal of the American Association for Cancer Research 30 (8) (2024)
Sudhir B Malla, Ryan M Byrne, Maxime W Lafarge, Shania M Corry, Natalie C Fisher, Petros K Tsantoulis, Megan L Mills, Rachel A Ridgway, Tamsin R M Lannagan, Arafath K Najumudeen, Kathryn L Gilroy, Raheleh Amirkhah, Sarah L Maguire, Eoghan J Mulholland, Hayley L Belnoue-Davis, Elena Grassi, Marco Viviani, Emily Rogan, Keara L Redmond, Svetlana Sakhnevych, Aoife J McCooey, Courtney Bull, Emily Hoey, Nicoleta Sinevici, Holly Hall, Baharak Ahmaderaghi, Enric Domingo, Andrew Blake, Susan D Richman, Claudio Isella, Crispin Miller, Andrea Bertotti, Livio Trusolino, Maurice B Loughrey, Emma M Kerr, Sabine Tejpar, Timothy S Maughan, Mark Lawler, Andrew D Campbell, Simon J Leedham, Viktor Hendrik Koelzer, Owen James Sansom, Philip David Dunne
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature genetics (2024)
Patrick Loi, Amy E Schade, Carrie L Rodriguez, Anjana Krishnan, Naiara Perurena, Van T M Nguyen, Yilin Xu, Marina Watanabe, Rachel A Davis, Alycia Gardner, Natalie F Pilla, Kaia Mattioli, Olesja Popow, Nuray Gunduz, Tamsin R M Lannagan, Samantha Fitzgerald, Ewa T Sicinska, Jia-Ren Lin, William Tan, Lauren K Brais, Kevin M Haigis, Marios Giannakis, Kimmie Ng, Sandro Santagata, Kristian Helin, Owen James Sansom, Karen Cichowski
Epigenetic and oncogenic inhibitors cooperatively drive differentiation and kill KRAS-mutant colorectal cancers. Cancer discovery (2024)
Brooke A Pereira, Shona Ritchie, Cecilia R Chambers, Katie A Gordon, Astrid Magenau, Kendelle J Murphy, Max Nobis, Victoria M Tyma, Ying Fei Liew, Morghan C Lucas, Marjan Mojtabavi Naeini, Deborah S Barkauskas, Diego Chacon-Fajardo, Anna E Howell, Amelia L Parker, Sean C Warren, Daniel A Reed, Victoria Lee, Xanthe L Metcalf, Young-Kyung Lee, Luke P O'Regan, Jessie Zhu, Michael Trpceski, Angela R M Kurz, Janett Stoehr, Romain Rouet, Xufeng Lin, Jessica L Chitty, Sean Porazinski, Sunny Z Wu, Elysse C Filipe, Antonia L Cadell, Holly Holliday, Jessica Yang, Michael Papanicolaou, Ruth J Lyons, Anaiis Zaratzian, Michael Tayao, Andrew Da Silva, Claire Vennin, Julia X Yin, Alysha B Dew, Paul J McMillan, Leonard D Goldstein, Ira W Deveson, David R Croucher, Michael Susithiran Samuel, Hao-Wen Sim, Marcel Batten, Lorraine A Chantrill, Sean M Grimmond, Anthony J Gill, Jaswinder Samra, Thomas R Jeffry Evans, Takako Sasaki, Tri Giang Phan, Alexander Swarbrick, Owen James Sansom, Jennifer P Morton, null null, null null, Marina Pajic, Benjamin L Parker, David Herrmann, Thomas R Cox, Paul Timpson
Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response. Science advances 10 (27) (2024)
Brooke A Pereira, Shona Ritchie, Cecilia R Chambers, Katie A Gordon, Astrid Magenau, Kendelle J Murphy, Max Nobis, Victoria M Tyma, Ying Fei Liew, Morghan C Lucas, Marjan Mojtabavi Naeini, Deborah S Barkauskas, Diego Chacon-Fajardo, Anna E Howell, Amelia L Parker, Sean C Warren, Daniel A Reed, Victoria Lee, Xanthe L Metcalf, Young-Kyung Lee, Luke P O'Regan, Jessie Zhu, Michael Trpceski, Angela R M Kurz, Janett Stoehr, Romain Rouet, Xufeng Lin, Jessica L Chitty, Sean Porazinski, Sunny Z Wu, Elysse C Filipe, Antonia L Cadell, Holly Holliday, Jessica Yang, Michael Papanicolaou, Ruth J Lyons, Anaiis Zaratzian, Michael Tayao, Andrew Da Silva, Claire Vennin, Julia X Yin, Alysha B Dew, Paul J McMillan, Leonard D Goldstein, Ira W Deveson, David R Croucher, Michael Susithiran Samuel, Hao-Wen Sim, Marcel Batten, Lorraine A Chantrill, Sean M Grimmond, Anthony J Gill, Jaswinder Samra, Thomas R Jeffry Evans, Takako Sasaki, Tri Giang Phan, Alexander Swarbrick, Owen James Sansom, Jennifer P Morton, null null, null null, Marina Pajic, Benjamin L Parker, David Herrmann, Thomas R Cox, Paul Timpson
Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response. Science advances 10 (27) (2024)
Sudhir B Malla, Ryan M Byrne, Maxime W Lafarge, Shania M Corry, Natalie C Fisher, Petros K Tsantoulis, Megan L Mills, Rachel A Ridgway, Tamsin R M Lannagan, Arafath K Najumudeen, Kathryn L Gilroy, Raheleh Amirkhah, Sarah L Maguire, Eoghan J Mulholland, Hayley L Belnoue-Davis, Elena Grassi, Marco Viviani, Emily Rogan, Keara L Redmond, Svetlana Sakhnevych, Aoife J McCooey, Courtney Bull, Emily Hoey, Nicoleta Sinevici, Holly Hall, Baharak Ahmaderaghi, Enric Domingo, Andrew Blake, Susan D Richman, Claudio Isella, Crispin Miller, Andrea Bertotti, Livio Trusolino, Maurice B Loughrey, Emma M Kerr, Sabine Tejpar, null null, Timothy S Maughan, Mark Lawler, Andrew D Campbell, Simon J Leedham, Viktor Hendrik Koelzer, Owen James Sansom, Philip David Dunne
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature genetics 56 (3) (2024)
Rana Fetit, Alistair Stewart McLaren, Mark White, Megan L Mills, John Falconer, Xabier Cortes-Lavaud, Kathryn L Gilroy, Tamsin R M Lannagan, Rachel A Ridgway, Colin Nixon, Varushka Naiker, Renee Njunge, Cassie J Clarke, Declan Whyte, Kristina Kirschner, Rene Jackstadt, James C Norman, Leo M Carlin, Andrew D Campbell, Owen James Sansom, Colin W Steele
Characterising neutrophil subtypes in cancer using scRNA sequencing demonstrates the importance of IL-1β/CXCR2 axis in generation of metastasis specific neutrophils. Cancer research communications (2024)
Andreas Dannhorn, Emine Kazanc, Lucy Flint, Fei Guo, Alfie Carter, Andrew R Hall, Stewart A Jones, George Poulogiannis, Simon T Barry, Owen James Sansom, Josephine Bunch, Zoltan Takats, Richard J A Goodwin
Morphological and molecular preservation through universal preparation of fresh-frozen tissue samples for multimodal imaging workflows. Nature protocols (2024)
Sudhir B Malla, Ryan M Byrne, Maxime W Lafarge, Shania M Corry, Natalie C Fisher, Petros K Tsantoulis, Megan L Mills, Rachel A Ridgway, Tamsin R M Lannagan, Arafath K Najumudeen, Kathryn L Gilroy, Raheleh Amirkhah, Sarah L Maguire, Eoghan J Mulholland, Hayley L Belnoue-Davis, Elena Grassi, Marco Viviani, Emily Rogan, Keara L Redmond, Svetlana Sakhnevych, Aoife J McCooey, Courtney Bull, Emily Hoey, Nicoleta Sinevici, Holly Hall, Baharak Ahmaderaghi, Enric Domingo, Andrew Blake, Susan D Richman, Claudio Isella, Crispin Miller, Andrea Bertotti, Livio Trusolino, Maurice B Loughrey, Emma M Kerr, Sabine Tejpar, Timothy S Maughan, Mark Lawler, Andrew D Campbell, Simon J Leedham, Viktor Hendrik Koelzer, Owen James Sansom, Philip David Dunne
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature genetics 56 (3) (2024)
Sudhir B Malla, Ryan M Byrne, Maxime W Lafarge, Shania M Corry, Natalie C Fisher, Petros K Tsantoulis, Megan L Mills, Rachel A Ridgway, Tamsin R M Lannagan, Arafath K Najumudeen, Kathryn L Gilroy, Raheleh Amirkhah, Sarah L Maguire, Eoghan J Mulholland, Hayley L Belnoue-Davis, Elena Grassi, Marco Viviani, Emily Rogan, Keara L Redmond, Svetlana Sakhnevych, Aoife J McCooey, Courtney Bull, Emily Hoey, Nicoleta Sinevici, Holly Hall, Baharak Ahmaderaghi, Enric Domingo, Andrew Blake, Susan D Richman, Claudio Isella, Crispin Miller, Andrea Bertotti, Livio Trusolino, Maurice B Loughrey, Emma M Kerr, Sabine Tejpar, null null, Timothy S Maughan, Mark Lawler, Andrew D Campbell, Simon J Leedham, Viktor Hendrik Koelzer, Owen James Sansom, Philip David Dunne
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature genetics 56 (3) (2024)
Gaurav Malviya, Tamsin R M Lannagan, Emma Johnson, Agata Mackintosh, Robert Bielik, Adam Peters, Dmitry Soloviev, Manikandan Kadirvel, Rene Jackstadt, Colin Nixon, Kathryn L Gilroy, Andrew D Campbell, Owen James Sansom, David Y Lewis
Noninvasive Stratification of Colon Cancer by Multiplex PET Imaging. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Rana Fetit, Alistair Stewart McLaren, Mark White, Megan L Mills, John Falconer, Xabier Cortes-Lavaud, Kathryn L Gilroy, Tamsin R M Lannagan, Rachel A Ridgway, Colin Nixon, Varushka Naiker, Renee Njunge, Cassie J Clarke, Declan Whyte, Kristina Kirschner, Rene Jackstadt, James C Norman, Leo M Carlin, Andrew D Campbell, Owen James Sansom, Colin W Steele
Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-specific Neutrophils. Cancer research communications 4 (2) (2024)
Owen James Sansom, Debora Bogani, Linus Reichenbach, Sara Wells
Negative equity - the value of reporting negative results. Disease models & mechanisms 17 (8) (2024)
Sudhir B Malla, Ryan M Byrne, Maxime W Lafarge, Shania M Corry, Natalie C Fisher, Petros K Tsantoulis, Megan L Mills, Rachel A Ridgway, Tamsin R M Lannagan, Arafath K Najumudeen, Kathryn L Gilroy, Raheleh Amirkhah, Sarah L Maguire, Eoghan J Mulholland, Hayley L Belnoue-Davis, Elena Grassi, Marco Viviani, Emily Rogan, Keara L Redmond, Svetlana Sakhnevych, Aoife J McCooey, Courtney Bull, Emily Hoey, Nicoleta Sinevici, Holly Hall, Baharak Ahmaderaghi, Enric Domingo, Andrew Blake, Susan D Richman, Claudio Isella, Crispin Miller, Andrea Bertotti, Livio Trusolino, Maurice B Loughrey, Emma M Kerr, Sabine Tejpar, Timothy S Maughan, Mark Lawler, Andrew D Campbell, Simon J Leedham, Viktor Hendrik Koelzer, Owen James Sansom, Philip David Dunne
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature genetics 56 (3) (2024)
Sudhir B Malla, Ryan M Byrne, Maxime W Lafarge, Shania M Corry, Natalie C Fisher, Petros K Tsantoulis, Megan L Mills, Rachel A Ridgway, Tamsin R M Lannagan, Arafath K Najumudeen, Kathryn L Gilroy, Raheleh Amirkhah, Sarah L Maguire, Eoghan J Mulholland, Hayley L Belnoue-Davis, Elena Grassi, Marco Viviani, Emily Rogan, Keara L Redmond, Svetlana Sakhnevych, Aoife J McCooey, Courtney Bull, Emily Hoey, Nicoleta Sinevici, Holly Hall, Baharak Ahmaderaghi, Enric Domingo, Andrew Blake, Susan D Richman, Claudio Isella, Crispin Miller, Andrea Bertotti, Livio Trusolino, Maurice B Loughrey, Emma M Kerr, Sabine Tejpar, Timothy S Maughan, Mark Lawler, Andrew D Campbell, Simon J Leedham, Viktor Hendrik Koelzer, Owen James Sansom, Philip David Dunne
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature genetics 56 (3) (2024)
Arafath K Najumudeen, Sigrid K Fey, Laura M Millett, Catriona A Ford, Kathryn Gilroy, Nuray Gunduz, Rachel A Ridgway, Eve Anderson, Douglas Strathdee, William Clark, Colin Nixon, Jennifer P Morton, Andrew D Campbell, Owen James Sansom
KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo. Nature communications 15 (1) (2024)
Rana Fetit, Alistair Stewart McLaren, Mark White, Megan L Mills, John Falconer, Xabier Cortes-Lavaud, Kathryn L Gilroy, Tamsin R M Lannagan, Rachel A Ridgway, Colin Nixon, Varushka Naiker, Renee Njunge, Cassie J Clarke, Declan Whyte, Kristina Kirschner, Rene Jackstadt, James C Norman, Leo M Carlin, Andrew D Campbell, Owen James Sansom, Colin W Steele
Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-specific Neutrophils. Cancer research communications 4 (2) (2024)
Sudhir B Malla, Ryan M Byrne, Maxime W Lafarge, Shania M Corry, Natalie C Fisher, Petros K Tsantoulis, Megan L Mills, Rachel A Ridgway, Tamsin R M Lannagan, Arafath K Najumudeen, Kathryn L Gilroy, Raheleh Amirkhah, Sarah L Maguire, Eoghan J Mulholland, Hayley L Belnoue-Davis, Elena Grassi, Marco Viviani, Emily Rogan, Keara L Redmond, Svetlana Sakhnevych, Aoife J McCooey, Courtney Bull, Emily Hoey, Nicoleta Sinevici, Holly Hall, Baharak Ahmaderaghi, Enric Domingo, Andrew Blake, Susan D Richman, Claudio Isella, Crispin Miller, Andrea Bertotti, Livio Trusolino, Maurice B Loughrey, Emma M Kerr, Sabine Tejpar, Timothy S Maughan, Mark Lawler, Andrew D Campbell, Simon J Leedham, Viktor Hendrik Koelzer, Owen James Sansom, Philip David Dunne
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature genetics 56 (3) (2024)
Dritan Liko, Louise Mitchell, Kirsteen J Campbell, Rachel A Ridgway, Carolyn Jones, Kate Dudek, Ayala King, Sheila Bryson, David Stevenson, Karen Blyth, Douglas Strathdee, Jennifer P Morton, Thomas G Bird, John R P Knight, Anne E Willis, Owen James Sansom
Correction to: Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell death and differentiation (2024)
Gaurav Malviya, Tamsin R M Lannagan, Emma Johnson, Agata Mackintosh, Robert Bielik, Adam Peters, Dmitry Soloviev, Manikandan Kadirvel, Rene Jackstadt, Colin Nixon, Kathryn L Gilroy, Andrew D Campbell, Owen James Sansom, David Y Lewis
Noninvasive Stratification of Colon Cancer by Multiplex PET Imaging. Clinical cancer research : an official journal of the American Association for Cancer Research 30 (8) (2024)
Sudhir B Malla, Ryan M Byrne, Maxime W Lafarge, Shania M Corry, Natalie C Fisher, Petros K Tsantoulis, Megan L Mills, Rachel A Ridgway, Tamsin R M Lannagan, Arafath K Najumudeen, Kathryn L Gilroy, Raheleh Amirkhah, Sarah L Maguire, Eoghan J Mulholland, Hayley L Belnoue-Davis, Elena Grassi, Marco Viviani, Emily Rogan, Keara L Redmond, Svetlana Sakhnevych, Aoife J McCooey, Courtney Bull, Emily Hoey, Nicoleta Sinevici, Holly Hall, Baharak Ahmaderaghi, Enric Domingo, Andrew Blake, Susan D Richman, Claudio Isella, Crispin Miller, Andrea Bertotti, Livio Trusolino, Maurice B Loughrey, Emma M Kerr, Sabine Tejpar, null null, Timothy S Maughan, Mark Lawler, Andrew D Campbell, Simon J Leedham, Viktor Hendrik Koelzer, Owen James Sansom, Philip David Dunne
Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature genetics (2024)
Sudhir B Malla, Ryan M Byrne, Maxime W Lafarge, Shania M Corry, Natalie C Fisher, Petros K Tsantoulis, Megan L Mills, Rachel A Ridgway, Tamsin R M Lannagan, Arafath K Najumudeen, Kathryn L Gilroy, Raheleh Amirkhah, Sarah L Maguire, Eoghan J Mulholland, Hayley L Belnoue-Davis, Elena Grassi, Marco Viviani, Emily Rogan, Keara L Redmond, Svetlana Sakhnevych, Aoife J McCooey, Courtney Bull, Emily Hoey, Nicoleta Sinevici, Holly Hall, Baharak Ahmaderaghi, Enric Domingo, Andrew Blake, Susan D Richman, Claudio Isella, Crispin Miller, Andrea Bertotti, Livio Trusolino, Maurice B Loughrey, Emma M Kerr, Sabine Tejpar, null null, Timothy S Maughan, Mark Lawler, Andrew D Campbell, Simon J Leedham, Viktor Hendrik Koelzer, Owen James Sansom, Philip David Dunne
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature genetics 56 (3) (2024)
Sudhir B Malla, Ryan M Byrne, Maxime W Lafarge, Shania M Corry, Natalie C Fisher, Petros K Tsantoulis, Megan L Mills, Rachel A Ridgway, Tamsin R M Lannagan, Arafath K Najumudeen, Kathryn L Gilroy, Raheleh Amirkhah, Sarah L Maguire, Eoghan J Mulholland, Hayley L Belnoue-Davis, Elena Grassi, Marco Viviani, Emily Rogan, Keara L Redmond, Svetlana Sakhnevych, Aoife J McCooey, Courtney Bull, Emily Hoey, Nicoleta Sinevici, Holly Hall, Baharak Ahmaderaghi, Enric Domingo, Andrew Blake, Susan D Richman, Claudio Isella, Crispin Miller, Andrea Bertotti, Livio Trusolino, Maurice B Loughrey, Emma M Kerr, Sabine Tejpar, Timothy S Maughan, Mark Lawler, Andrew D Campbell, Simon J Leedham, Viktor Hendrik Koelzer, Owen James Sansom, Philip David Dunne
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature genetics (2024)
Arafath K Najumudeen, Sigrid K Fey, Laura M Millett, Catriona A Ford, Kathryn Gilroy, Nuray Gunduz, Rachel A Ridgway, Eve Anderson, Douglas Strathdee, William Clark, Colin Nixon, Jennifer P Morton, Andrew D Campbell, Owen James Sansom
KRAS allelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancer in vivo. Nature communications 15 (1) (2024)
Rana Fetit, Alistair Stewart McLaren, Mark White, Megan L Mills, John Falconer, Xabier Cortes-Lavaud, Kathryn L Gilroy, Tamsin R M Lannagan, Rachel A Ridgway, Colin Nixon, Varushka Naiker, Renee Njunge, Cassie J Clarke, Declan Whyte, Kristina Kirschner, Rene Jackstadt, James C Norman, Leo M Carlin, Andrew D Campbell, Owen James Sansom, Colin W Steele
Characterising neutrophil subtypes in cancer using scRNA sequencing demonstrates the importance of IL-1β/CXCR2 axis in generation of metastasis specific neutrophils. Cancer research communications (2024)
Brooke A Pereira, Shona Ritchie, Cecilia R Chambers, Katie A Gordon, Astrid Magenau, Kendelle J Murphy, Max Nobis, Victoria M Tyma, Ying Fei Liew, Morghan C Lucas, Marjan Mojtabavi Naeini, Deborah S Barkauskas, Diego Chacon-Fajardo, Anna E Howell, Amelia L Parker, Sean C Warren, Daniel A Reed, Victoria Lee, Xanthe L Metcalf, Young-Kyung Lee, Luke P O'Regan, Jessie Zhu, Michael Trpceski, Angela R M Kurz, Janett Stoehr, Romain Rouet, Xufeng Lin, Jessica L Chitty, Sean Porazinski, Sunny Z Wu, Elysse C Filipe, Antonia L Cadell, Holly Holliday, Jessica Yang, Michael Papanicolaou, Ruth J Lyons, Anaiis Zaratzian, Michael Tayao, Andrew Da Silva, Claire Vennin, Julia X Yin, Alysha B Dew, Paul J McMillan, Leonard D Goldstein, Ira W Deveson, David R Croucher, Michael Susithiran Samuel, Hao-Wen Sim, Marcel Batten, Lorraine A Chantrill, Sean M Grimmond, Anthony J Gill, Jaswinder Samra, Thomas R Jeffry Evans, Takako Sasaki, Tri Giang Phan, Alexander Swarbrick, Owen James Sansom, Jennifer P Morton, null null, null null, Marina Pajic, Benjamin L Parker, David Herrmann, Thomas R Cox, Paul Timpson
Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response. Science advances 10 (27) (2024)
Gaurav Malviya, Tamsin R M Lannagan, Emma Johnson, Agata Mackintosh, Robert Bielik, Adam Peters, Dmitry Soloviev, Manikandan Kadirvel, Rene Jackstadt, Colin Nixon, Kathryn L Gilroy, Andrew D Campbell, Owen James Sansom, David Y Lewis
Noninvasive Stratification of Colon Cancer by Multiplex PET Imaging. Clinical cancer research : an official journal of the American Association for Cancer Research 30 (8) (2024)
Johanna Lilja, Jasmin Kaivola, James R W Conway, Joni Vuorio, Hanna Parkkola, Pekka Roivas, Michal Dibus, Megan R Chastney, Taru Varila, Guillaume Jacquemet, Emilia Peuhu, Emily Wang, Ulla Pentikäinen, Itziar Martinez D Posada, Hellyeh Hamidi, Arafath K Najumudeen, Owen James Sansom, Igor L Barsukov, Daniel Kwaku Abankwa, Ilpo Vattulainen, Marko Salmi, Johanna Ivaska
SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers. Nature communications 15 (1) (2024)
Sudhir B Malla, Ryan M Byrne, Maxime W Lafarge, Shania M Corry, Natalie C Fisher, Petros K Tsantoulis, Megan L Mills, Rachel A Ridgway, Tamsin R M Lannagan, Arafath K Najumudeen, Kathryn L Gilroy, Raheleh Amirkhah, Sarah L Maguire, Eoghan J Mulholland, Hayley L Belnoue-Davis, Elena Grassi, Marco Viviani, Emily Rogan, Keara L Redmond, Svetlana Sakhnevych, Aoife J McCooey, Courtney Bull, Emily Hoey, Nicoleta Sinevici, Holly Hall, Baharak Ahmaderaghi, Enric Domingo, Andrew Blake, Susan D Richman, Claudio Isella, Crispin Miller, Andrea Bertotti, Livio Trusolino, Maurice B Loughrey, Emma M Kerr, Sabine Tejpar, Timothy S Maughan, Mark Lawler, Andrew D Campbell, Simon J Leedham, Viktor Hendrik Koelzer, Owen James Sansom, Philip David Dunne
Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer. Nature genetics 56 (3) (2024)
James R W Conway, Sean C Warren, Young-Kyung Lee, Andrew T McCulloch, Astrid Magenau, Victoria Lee, Xanthe L Metcalf, Janett Stoehr, Katharina Haigh, Lea Abdulkhalek, Cristian S Guaman, Daniel A Reed, Kendelle J Murphy, Brooke A Pereira, Pauline Mélénec, Cecilia R Chambers, Sharissa L Latham, Helen Lenthall, Elissa K Deenick, Yuanqing Ma, Tri Giang Phan, Elgene Lim, Anthony M Joshua, Stacey N Walters, Shane T Grey, Yan-Chuan Shi, Lei Zhang, Herbert Herzog, David R Croucher, Andy Philp, Colinda L G J Scheele, David Herrmann, Owen James Sansom, Jennifer P Morton, Antonella Papa, Jody Jonathan Haigh, Max Nobis, Paul Timpson
Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse. Science advances 9 (17) (2023)
James R W Conway, Sean C Warren, Young-Kyung Lee, Andrew T McCulloch, Astrid Magenau, Victoria Lee, Xanthe L Metcalf, Janett Stoehr, Katharina Haigh, Lea Abdulkhalek, Cristian S Guaman, Daniel A Reed, Kendelle J Murphy, Brooke A Pereira, Pauline Mélénec, Cecilia R Chambers, Sharissa L Latham, Helen Lenthall, Elissa K Deenick, Yuanqing Ma, Tri Giang Phan, Elgene Lim, Anthony M Joshua, Stacey N Walters, Shane T Grey, Yan-Chuan Shi, Lei Zhang, Herbert Herzog, David R Croucher, Andy Philp, Colinda L G J Scheele, David Herrmann, Owen James Sansom, Jennifer P Morton, Antonella Papa, Jody Jonathan Haigh, Max Nobis, Paul Timpson
Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse. Science advances 9 (17) (2023)
Anna L M Smith, Julia C Whitehall, Carla Bradshaw, David Gay, Fiona Robertson, Alasdair P Blain, Gavin Hudson, Angela Pyle, David Houghton, Matthew Hunt, James N Sampson, Craig Stamp, Grace Mallett, Shoba Amarnath, Jack Leslie, Fiona Oakley, Laura Wilson, Angela Baker, Oliver M Russell, Riem Johnson, Claire A Richardson, Bhavana Gupta, Iain McCallum, Stuart A C McDonald, Seamus Kelly, John C Mathers, Rakesh Heer, Robert W Taylor, Neil D Perkins, Doug M Turnbull, Owen James Sansom, Laura C Greaves
Author Correction: Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis. Nature cancer 2 (1) (2023)
Colin S Wood, Kathryn A F Pennel, Holly Leslie, Assya Legrini, Andrew J Cameron, Lydia Melissourgou-Syka, Jean A Quinn, Hester C van Wyk, Jennifer Hay, Antonia K Roseweir, Colin Nixon, Campbell Stuart Roxburgh, Donald C McMillan, Andrew V Biankin, Owen James Sansom, Paul G Horgan, Joanne Edwards, Colin W Steele, Nigel B Jamieson
Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases. Cancer research 83 (8) (2023)
Simon T Barry, Dmitry I Gabrilovich, Owen James Sansom, Andrew D Campbell, Jennifer P Morton
Therapeutic targeting of tumour myeloid cells. Nature reviews. Cancer (2023)
Fuhui Chen, Sevim B Gurler, David Novo, Cigdem Selli, Denis G Alferez, Secil Eroglu, Kyriaki Pavlou, Jingwei Zhang, Andrew H Sims, Neil E Humphreys, Antony Adamson, Andrew D Campbell, Owen James Sansom, Cathy Tournier, Robert B Clarke, Keith Brennan, Charles H Streuli, Ahmet Ucar
RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells. Oncogene 42 (9) (2023)
Peter Bailey, Rachel A Ridgway, Patrizia Cammareri, Mairi Treanor-Taylor, Ulla-Maja Bailey, Christina Schoenherr, Max Bone, Daniel Schreyer, Karin Purdie, Jason Thomson, William Rickaby, Rene Jackstadt, Andrew D Campbell, Emmanouil Dimonitsas, Alexander J Stratigos, Sarah T Arron, Jun Wang, Karen Blyth, Charlotte M Proby, Catherine A Harwood, Owen James Sansom, Irene M Leigh, Gareth J Inman
Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression. Nature communications 14 (1) (2023)
Dustin J Flanagan, Raheleh Amirkhah, David F Vincent, Nuray Gunduz, Pauline Gentaz, Patrizia Cammareri, Aoife J McCooey, Amy M B McCorry, Natalie C Fisher, Hayley L Belnoue-Davis, Rachel A Ridgway, Jeroen Lohuis, Joshua D G Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Clark, Ann Hedley, Elke K Markert, Douglas Strathdee, Laurent Bartholin, Keara L Redmond, Emma M Kerr, Daniel B Longley, Fiona Ginty, Sanghee Cho, Helen G Coleman, Maurice B Loughrey, Alberto Bardelli, Timothy S Maughan, Andrew D Campbell, Mark Lawler, Simon J Leedham, Simon T Barry, Gareth J Inman, Jacco van Rheenen, Philip David Dunne, Owen James Sansom
Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features. Nature communications 14 (1) (2023)
Fuhui Chen, Sevim B Gurler, David Novo, Cigdem Selli, Denis G Alferez, Secil Eroglu, Kyriaki Pavlou, Jingwei Zhang, Andrew H Sims, Neil E Humphreys, Antony Adamson, Andrew D Campbell, Owen James Sansom, Cathy Tournier, Robert B Clarke, Keith Brennan, Charles H Streuli, Ahmet Ucar
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β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancer. Cancer immunology research (2023)
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Accounting for intensity variation in image analysis of large-scale multiplexed clinical trial datasets. The journal of pathology. Clinical research (2023)
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RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells. Oncogene 42 (9) (2023)
Lydia Melissourgou-Syka, Michael A Gillespie, Sean Michael O'Cathail, Owen James Sansom, Colin W Steele, Campbell Stuart Roxburgh
A Review of Scheduling Strategies for Radiotherapy and Immune Checkpoint Inhibition in Locally Advanced Rectal Cancer. Journal of immunotherapy and precision oncology 6 (4) (2023)
Johan Vande Voorde, Rory T Steven, Arafath K Najumudeen, Catriona A Ford, Alex Dexter, Ariadna Gonzalez-Fernandez, Chelsea J Nikula, Yuchen Xiang, Lauren Ford, Stefania Maneta Stavrakaki, Kathryn L Gilroy, Lucas B Zeiger, Kathryn Pennel, Phimmada Hatthakarnkul, Efstathios A Elia, Ammar Nasif, Teresa Murta, Eftychios Manoli, Sam Mason, Michael Gillespie, Tamsin R M Lannagan, Nikola Vlahov, Rachel A Ridgway, Colin Nixon, Alexander Raven, Megan Mills, Dimitris Athineos, Georgios Kanellos, Craig Nourse, David M Gay, Mark Hughes, Amy Burton, Bin Yan, Katherine Sellers, Vincen Wu, Kobe De Ridder, Engy Shokry, Alejandro Huerta Uribe, William Clark, Graeme Clark, Kristina Kirschner, Bernard Thienpont, Vivian Sze Wing Li, Oliver D K Maddocks, Simon T Barry, Richard J A Goodwin, James Macalister Kinross, Joanne Edwards, Mariia O Yuneva, David Sumpton, Zoltán Takáts, Andrew D Campbell, Josephine Bunch, Owen James Sansom
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature metabolism (2023)
Simon T Barry, Dmitry I Gabrilovich, Owen James Sansom, Andrew D Campbell, Jennifer P Morton
Therapeutic targeting of tumour myeloid cells. Nature reviews. Cancer (2023)
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Dustin J Flanagan, Raheleh Amirkhah, David F Vincent, Nuray Gunduz, Pauline Gentaz, Patrizia Cammareri, Aoife J McCooey, Amy M B McCorry, Natalie C Fisher, Hayley L Belnoue-Davis, Rachel A Ridgway, Jeroen Lohuis, Joshua D G Leach, Rene Jackstadt, Kathryn Gilroy, Elisa Mariella, Colin Nixon, William Clark, Ann Hedley, Elke K Markert, Douglas Strathdee, Laurent Bartholin, Keara L Redmond, Emma M Kerr, Daniel B Longley, Fiona Ginty, Sanghee Cho, Helen G Coleman, Maurice B Loughrey, Alberto Bardelli, Timothy S Maughan, Andrew D Campbell, Mark Lawler, Simon J Leedham, Simon T Barry, Gareth J Inman, Jacco van Rheenen, Philip David Dunne, Owen James Sansom
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A new network for the synergistic translation of mouse research. Disease models & mechanisms 15 (9) (2022)
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Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (18) (2022)
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Andrew M Kidger, Mark K Saville, Linda K Rushworth, Jane Davidson, Julia Stellzig, Motoharu Ono, Ludwig A Kuebelsbeck, Klaus-Peter Janssen, Bernhard Holzmann, Jennifer P Morton, Owen James Sansom, Christopher J Caunt, Stephen M Keyse
Suppression of mutant Kirsten-RAS (KRAS G12D )-driven pancreatic carcinogenesis by dual-specificity MAP kinase phosphatases 5 and 6. Oncogene 41 (20) (2022)
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Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop. Cell death & disease 13 (2) (2022)
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Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression. Cancer research 82 (14) (2022)
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Retrograde movements determine effective stem cell numbers in the intestine. Nature 607 (7919) (2022)
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Evaluating data integrity in ribosome footprinting datasets through modelled polysome profiles. Nucleic acids research 50 (19) (2022)
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Hepatic glutamine synthetase controls N 5 -methylglutamine in homeostasis and cancer. Nature chemical biology (2022)
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The pathogenesis of mesothelioma is driven by a dysregulated translatome. Nature communications 12 (1) (2021)
George Sharbeen, Joshua A McCarroll, Anouschka Akerman, Chantal Kopecky, Janet Youkhana, John Kokkinos, Jeff Holst, Cyrille Boyer, Mert Erkan, David Goldstein, Paul Timpson, Thomas R Cox, Brooke A Pereira, Jessica L Chitty, Sigrid K Fey, Arafath K Najumudeen, Andrew D Campbell, Owen James Sansom, Rosa Mistica C Ignacio, Stephanie Naim, Jie Liu, Nelson Russia, Julia Lee, Angela Chou, Amber Johns, Anthony J Gill, Estrella Gonzales-Aloy, Val Gebski, Yi Fang Guan, Marina Pajic, Nigel Turner, Minoti V Apte, Thomas P Davis, Jennifer P Morton, Koroush S Haghighi, Jorjina Kasparian, Benjamin J McLean, Yordanos F I Setargew, Phoebe A Phillips, null null
Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition. Cancer research 81 (13) (2021)
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BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer. Cell death and differentiation 28 (12) (2021)
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Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas. Science advances 7 (47) (2021)
Nathalie Sphyris, Michael C Hodder, Owen James Sansom
Subversion of Niche-Signalling Pathways in Colorectal Cancer: What Makes and Breaks the Intestinal Stem Cell. Cancers 13 (5) (2021)
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The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nature genetics 53 (1) (2021)
Louise van der Weyden, Victoria Harle, Gemma Turner, Victoria Offord, Vivek Iyer, Alastair P Droop, Agnieszka Swiatkowska, Roy Rabbie, Andrew D Campbell, Owen James Sansom, Mercedes Calvo Pardo, Jyoti Sharma Choudhary, Ingrid Ferreira, Mark Tullett, Mark J Arends, Anneliese O Speak, David J Adams
CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation. Communications biology 4 (1) (2021)
Victoria Gudiño, Sebastian Öther-Gee Pohl, Caroline V Billard, Patrizia Cammareri, Alfonso Bolado, Stuart Aitken, David Stevenson, Adam E Hall, Mark Agostino, John Cassidy, Colin Nixon, Alexander von Kriegsheim, Paz Freile, Linda Popplewell, George Dickson, Laura Murphy, Ann Wheeler, Malcolm Dunlop, Farhat Din, Douglas Strathdee, Owen James Sansom, Kevin B Myant
RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways. Nature communications 12 (1) (2021)
Mylène Tajan, Marc Hennequart, Eric C Cheung, Fabio Zani, Andreas K Hock, Nathalie Legrave, Oliver D K Maddocks, Rachel A Ridgway, Dimitris Athineos, Alejandro Suarez-Bonnet, Robert L Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian Sze Wing Li, Georgios Vlachogiannis, Nicola Valeri, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, Karen Blyth, Owen James Sansom, Karen H Vousden
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy. Nature communications 12 (1) (2021)
Sarah E Minnis-Lyons, Sofía Ferreira-González, Niya Aleksieva, Tak Yung Man, Victoria L Gadd, Michael J Williams, Rachel V Guest, Wei-Yu Lu, Benjamin J Dwyer, Thomas Jamieson, Colin Nixon, Noémi K M van Hul, Frederic P Lemaigre, John McCafferty, Isabelle A Leclercq, Owen James Sansom, Luke Boulter, Stuart John Forbes
Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation. Science signaling 14 (688) (2021)
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Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status. Science advances 7 (40) (2021)
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Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis. Nature communications 12 (1) (2021)
Máté Nászai, Karen Bellec, Yachuan Yu, Alvaro Román-Fernández, Emma Sandilands, Joel Johansson, Andrew D Campbell, Jim C Norman, Owen James Sansom, David M Bryant Editor, Julia B Cordero
RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. eLife 10 (2021)
Sebastian Rune Nielsen, Jan E Strøbech, Edward R Horton, Rene Jackstadt, Anu Laitala, Marina C Bravo, Giorgia Maltese, Adina R D Jensen, Raphael Reuten, Maria Rafaeva, Saadia A Karim, Chang-Il Hwang, Luis Arnes, David A Tuveson, Owen James Sansom, Jennifer P Morton, Janine Terra Erler
Suppression of tumor-associated neutrophils by lorlatinib attenuates pancreatic cancer growth and improves treatment with immune checkpoint blockade. Nature communications 12 (1) (2021)
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Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer. eLife 10 (2021)
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Loss of autophagy affects melanoma development in a manner dependent on PTEN status. Cell death and differentiation 28 (4) (2021)
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Genetic Screens Identify a Context-Specific PI3K/p27Kip1 Node Driving Extrahepatic Biliary Cancer. Cancer discovery (2021)
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NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature 594 (7863) (2021)
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A RAC-GEF network critical for early intestinal tumourigenesis. Nature communications 12 (1) (2021)
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Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. Nature communications 11 (1) (2020)
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Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors. Nature communications 11 (1) (2020)
Fernanda G Kugeratski, Samuel J Atkinson, Lisa J Neilson, Sergio Lilla, John R P Knight, Jens Serneels, Amelie Juin, Shehab Ismail, David M Bryant, Elke K Markert, Laura M Machesky, Massimilliano Mazzone, Owen James Sansom, Sara R Zanivan
Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling. Science signaling 12 (567) (2019)
Stefanie Schmidt, David Gay, Friedrich Wilhelm Uthe, Sarah Denk, Madelon Paauwe, Niels Matthes, Markus Elmar Diefenbacher, Sheila Bryson, Fiona Clare Warrander, Florian Erhard, Carsten Patrick Ade, Apoorva Baluapuri, Susanne Walz, Rene Jackstadt, Catriona Ford, Georgios Vlachogiannis, Nicola Valeri, Christoph Otto, Christina Schülein-Völk, Katja Maurus, Werner Schmitz, John Raymond Philip Knight, Elmar Wolf, Douglas Strathdee, Almut Schulze, Christoph-Thomas Germer, Andreas Rosenwald, Owen James Sansom, Martin Eilers, Armin Wiegering
A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer. Nature cell biology 21 (11) (2019)
Dritan Liko, Louise Mitchell, Kirsteen J Campbell, Rachel A Ridgway, Carolyn Jones, Kate Dudek, Ayala King, Sheila Bryson, David Stevenson, Karen Blyth, Douglas Strathdee, Jennifer P Morton, Thomas G Bird, John R P Knight, Anne E Willis, Owen James Sansom
Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas. Cell death and differentiation 26 (12) (2019)
Claire Vennin, Pauline Mélénec, Romain Rouet, Max Nobis, Aurélie S Cazet, Kendelle J Murphy, David Herrmann, Daniel A Reed, Morghan C Lucas, Sean C Warren, Zehra Elgundi, Mark Pinese, Gabriella Kalna, Daniel Roden, Monisha Samuel, Anaiis Zaratzian, Shane T Grey, Andrew Da Silva, Wilfred Leung, null null, Suresh Mathivanan, Yingxiao Wang, Anthony W Braithwaite, Daniel Christ, Ales Benda, Ashleigh Parkin, Phoebe A Phillips, John M Whitelock, Anthony J Gill, Owen James Sansom, David R Croucher, Benjamin L Parker, Marina Pajic, Jennifer P Morton, Thomas R Cox, Paul Timpson
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan. Nature communications 10 (1) (2019)
Alexander Greenhough, Clare Bagley, Kate J Heesom, David B Gurevich, David Gay, Mark Bond, Tracey J Collard, Chris Paraskeva, Paul Martin, Owen James Sansom, Karim T A Malik, Ann Caroline Williams
Cancer cell adaptation to hypoxia involves a HIF-GPRC5A-YAP axis. EMBO molecular medicine 10 (11) (2019)
Rachana Patel, Janis Fleming, Ernest Mui, Carolyn Loveridge, Peter Repiscak, Arnaud Blomme, Victoria Harle, Mark Salji, Imran Ahmad, Katy Teo, Freddie C Hamdy, Ann Hedley, Niels van den Broek, Gillian Mackay, Joanne Edwards, Owen James Sansom, Hing Y Leung
Sprouty2 loss-induced IL6 drives castration-resistant prostate cancer through scavenger receptor B1. EMBO molecular medicine 10 (4) (2019)
Malini Menon, Richard Elliott, Leandra Bowers, Nicolae Balan, Rumana Rafiq, Sara Costa-Cabral, Felix Munkonge, Ines Trinidade, Roderick Porter, Andrew D Campbell, Emma R Johnson, Christina Esdar, Hans-Peter Buchstaller, Birgitta Leuthner, Felix Rohdich, Richard Schneider, Owen James Sansom, Dirk Wienke, Alan Ashworth, Christopher J Lord
A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors. Scientific reports 9 (1) (2019)
Natasha Malik, Karen M Dunn, Jennifer Cassels, Jodie Hay, Christopher Estell, Owen James Sansom, Alison M Michie
mTORC1 activity is essential for erythropoiesis and B cell lineage commitment. Scientific reports 9 (1) (2019)
David M Gay, Rachel A Ridgway, Miryam Müller, Michael C Hodder, Ann Hedley, William Clark, Joshua D Leach, Rene Jackstadt, Colin Nixon, David J Huels, Andrew D Campbell, Thomas G Bird, Owen James Sansom
Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer. Nature communications 10 (1) (2019)
David M Gay, Rachel A Ridgway, Miryam Müller, Michael C Hodder, Ann Hedley, William Clark, Joshua D Leach, Rene Jackstadt, Colin Nixon, David J Huels, Andrew D Campbell, Thomas G Bird, Owen James Sansom
Author Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer. Nature communications 10 (1) (2019)
Nadine Rohwer, Sandra Jumpertz, Merve Erdem, Antje Egners, Klaudia T Warzecha, Athanassios Fragoulis, Anja A Kühl, Rafael Kramann, Sabine Neuss, Ines Rudolph, Tobias Endermann, Christin Zasada, Ivayla Apostolova, Marco Gerling, Stefan Kempa, Russell Hughes, Claire E Lewis, Winfried Brenner, Maciej B Malinowski, Martin Stockmann, Lutz Schomburg, William James Faller, Owen James Sansom, Frank Tacke, Markus Morkel, Thorsten Cramer
Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis. Oncogene 38 (28) (2019)

Owen James Sansom.css-eqlu8i{font-size:small;padding-left:4px;} (O J Sansom, Owen Sansom, Owen J Sansom)

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Owen James Sansom (O J Sansom, Owen Sansom, Owen J Sansom)