Making Drug Approval Decisions in the Face of Uncertainty: Cumulative Evidence versus Value of Information.

Stijntje Willemijn Dijk Eline M Krijkamp Natalia KunstJeremy A LabrecqueCary P GrossAradhana PanditChia-Ping LuLoes E VisserJohn B WongM G Myriam Hunink

Published in: Medical decision making : an international journal of the Society for Medical Decision Making (2024)

This study reviews discrepancies between a reference standard (retrospective VOI, using hindsight information) and 3 conceivable real-time approaches to research-treatment decisions during a pandemic, suggesting suboptimal use of resources.Of all prospective decision-making approaches considered, VOI closely mirrored the reference standard, yielding the least expected value loss across our study timeline.This study illustrates the possible benefit of VOI results and the need for evidence accumulation accompanied by modeling in health technology assessment for emerging therapies.

Keyphrases

healthcare
decision making
sars cov
randomized controlled trial
health information
risk assessment
cross sectional
health promotion