Human A2-CAR T cells reject HLA-A2+ human islets transplanted into mice without inducing graft versus host disease.
Cara E EllisMajid MojibianShogo IdaVivian C W FungSøs SkovsøEmma McIverShannon O'DwyerTravis D WebberMitchell J S BraamNelly SaberTimothy J KiefferMegan K LevingsPublished in: bioRxiv : the preprint server for biology (2023)
Injection of A2-CAR T cells can be used to study rejection of human insulin-producing cells without the complication of xGVHD. The rapidity and synchrony of rejection will facilitate in vivo screening of new therapies designed to improve the success of isletreplacement therapies.