Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data.
Natalie C FisherRyan M ByrneHolly LeslieColin WoodAssya LegriniAndrew J CameronBaharak AhmaderaghiShania M CorrySudhir B MallaRaheleh AmirkhahAoife J McCooeyEmily RoganKeara L RedmondSvetlana SakhnevychEnric DomingoJames JacksonMaurice B LoughreySimon J LeedhamTimothy S MaughanMark LawlerOwen James SansomFelicity LamrockViktor Hendrik KoelzerNigel B JamiesonPhilip D DunnePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Efforts to faithfully align preclinical models of disease using phenotypically-designed GESs must ensure that the signatures themselves remain representative of the same biology when applied to clinical samples.