Journal Club: Efficacy and Safety of Voclosporin Versus Placebo for Lupus Nephritis (AURORA 1): A Double-Blind, Randomized, Multicenter, Placebo-Controlled, Phase 3 Trial.

Published in: ACR open rheumatology (2021)

Voclosporin in combination with mycophenolate mofetil (MMF) and low-dose steroids led to a clinically and statistically superior complete renal response rate versus MMF and low-dose steroids alone, with a comparable safety profile. This finding is an important advancement in the treatment of patients with active LN.

Keyphrases

double blind
low dose
placebo controlled
phase iii
clinical trial
high dose
phase ii
study protocol
open label
phase ii study
randomized controlled trial
cross sectional
radiation therapy
combination therapy
rectal cancer
replacement therapy