Tumor ENPP1 (CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer.
Borja Ruiz-Fernández de CórdobaHaritz MorenoKarmele ValenciaNaiara PerurenaPablo RuedasThomas WalleAlberto Pezonaga-TorresJuan HinojosaElisabeth GuruceagaAntonio Pineda-LucenaMarta Abengózar-MuelaDenis CochonneauCarolina ZanduetaSusana Martínez-CanariasAlvaro TeijeiraDaniel AjonaSergio Ortiz EspinosaXabier MoralesCarlos Ortiz de SolórzanoMarta SantistebanLuis I Ramos-GarcíaLaura GuembeVratislav StrnadDominique HeymannSandra Hervás-StubbsRuben PioMaría E Rodríguez-RuizCarlos E de AndreaSilvestre VincentIgnacio Melero BermejoFernando LecandaRafael Martinez-MongePublished in: Cancer discovery (2022)
CTC exploit the ENPP1/HP axis to promote local recurrence post-surgery and post-irradiation by subduing myeloid suppressor cells in breast tumors. Blocking this axis impairs tumor engraftment, impedes immunosuppression, and obliterates NET formation, unveiling new opportunities for therapeutic intervention to eradicate local relapse and ameliorate patient survival. This article is highlighted in the In This Issue feature, p. 1171.
Keyphrases
- induced apoptosis
- free survival
- cell cycle arrest
- randomized controlled trial
- minimally invasive
- early stage
- machine learning
- radiation induced
- bone marrow
- case report
- acute myeloid leukemia
- dendritic cells
- coronary artery bypass
- squamous cell carcinoma
- cell death
- deep learning
- signaling pathway
- immune response
- young adults
- coronary artery disease
- cell proliferation
- locally advanced
- pi k akt
- percutaneous coronary intervention