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Swelling and Antimicrobial Activity Characterization of a GO-Reinforced Gelatin-Whey Hydrogel.

Pompilia Mioara Purcea LopesDumitriţa MoldovanRadu FecheteDoina ProdanCarmen-Rodica PopMihaela Ancuţa RotarVioleta Popescu
Published in: Gels (Basel, Switzerland) (2022)
Whey-based hydrogel samples with increasing concentrations of graphene oxide (GO) were studied, against a control sample (M), for swelling behavior in light of nuclear magnetic resonance (NMR) and mathematical models of the diffusion process and for antibacterial activity. Graphene oxide (GO) is an optimal filler for whey-based hydrogels, giving them improved mechanical and swelling properties at low concentrations. Crosslinking induces a certain stiffness of the hydrogels, which is why only the first part of the swelling process (<60%) follows the first-order model, while during the whole time interval, the swelling process follows the second-order diffusion model. The NMR relaxometry results are consistent with the swelling behavior of GO-reinforced whey-gelatin composite hydrogels, showing that higher GO concentrations induce a higher degree of cross-linking and, therefore, lower swelling capacity. Only hydrogel samples with higher GO concentrations demonstrated antibacterial activity.
Keyphrases
  • hyaluronic acid
  • tissue engineering
  • magnetic resonance
  • drug delivery
  • wound healing
  • high resolution
  • drug release
  • extracellular matrix
  • computed tomography
  • contrast enhanced