One episode of low intensity aerobic exercise prior to systemic AAV9 administration augments transgene delivery to the heart and skeletal muscle.
Christina A PacakSilveli Suzuki-HatanoFatemeh KhadirAudrey L DaughertyMughil SriramvenugopalBennett J GosikerPeter B KangWilliam Todd CadePublished in: Journal of translational medicine (2023)
Our findings suggest that one episode of acute low intensity aerobic exercise improves AAV9 transduction of heart and skeletal muscle. This low-risk, cost effective intervention could be implemented in clinical trials of individuals with inherited cardioskeletal disease as a potential means of improving patient safety for human gene therapy.
Keyphrases
- gene therapy
- skeletal muscle
- patient safety
- clinical trial
- quality improvement
- insulin resistance
- heart failure
- endothelial cells
- liver failure
- randomized controlled trial
- atrial fibrillation
- respiratory failure
- drug induced
- induced pluripotent stem cells
- pluripotent stem cells
- metabolic syndrome
- adipose tissue
- risk assessment
- phase ii
- open label
- climate change
- study protocol
- acute respiratory distress syndrome