Triazine-pyridine chemistry for protein labelling on tyrosine.

Hongfei JiangQing ZhangYue ZhangHuxin FengHao JiangFan PuRi-Lei Yu Zheng ZhongChaoming WangYi Man Eva FungPilar BlascoYongxin LiTao Jiang Xuechen Li

Published in: Chemical communications (Cambridge, England) (2022)

Herein, we discover the new reactivity of the 1,3,5-triazine moiety reacting with a phenol group and report the development of biocompatible and catalyst-free triazine-pyridine chemistry (TPC) for tyrosine labelling under physiological conditions and profiling in the whole proteome. TPC exhibited high tyrosine chemoselectivity in biological systems after cysteine blocking, displayed potential in tyrosine-guided protein labelling, and had bio-compatibility in live cells.

Keyphrases

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