Environmental and Nutritional Parameters Modulating Genetic Expression for Virulence Factors of Clostridioides difficile .
Zoe MassetSathursha GunaratnamMathieu MilletteLynne V McFarlandMonique LacroixPublished in: Antibiotics (Basel, Switzerland) (2024)
Clostridioides difficile infections (CDIs) continue to be a persistent healthcare concern despite newer antibiotic treatments, enhanced infection control practices, and preventive strategies focused on restoring the protective intestinal microbial barrier. Recent strides in gene sequencing research have identified many genes regulating diverse virulence factors for CDIs. These genes may be over- or under-expressed when triggered by various environmental and nutritional factors. The aims of this paper are to review the important genes involved in C. difficile pathogenesis and to identify modifiable environmental, nutritional, and other factors that may trigger the expression of these genes and thus offer new strategies to prevent CDIs.
Keyphrases
- genome wide
- clostridium difficile
- healthcare
- poor prognosis
- genome wide identification
- escherichia coli
- pseudomonas aeruginosa
- staphylococcus aureus
- copy number
- dna methylation
- microbial community
- bioinformatics analysis
- primary care
- signaling pathway
- genome wide analysis
- life cycle
- risk assessment
- transcription factor
- cystic fibrosis
- health insurance