Bioactive Compounds from Lemon (Citrus limon) Extract Overcome TNF-α-Induced Insulin Resistance in Cultured Adipocytes.
Valeria SorrentiValeria ConsoliSalvo GrossoMarco RaffaeleMargherita AmentaGabriele BallistreriSimona FabroniPaolo RapisardaLuca VanellaPublished in: Molecules (Basel, Switzerland) (2021)
The consumption of plant-based food is important for health promotion, especially regarding the prevention and management of chronic diseases such as diabetes. We investigated the effects of a lemon extract (LE), containing ≥20.0% total flavanones and ≥1.0% total hydroxycinnamic acids, on insulin signaling in murine 3T3-L1 adipocytes treated with TNF-α, which was used to mimic in vitro the insulin resistance condition that characterizes diabetes mellitus. Our results showed LE increased PPARγ, GLUT4 and DGAT-1 levels, demonstrating the potential of this lemon extract in the management of insulin resistance conditions associated with TNF-α pathway activation. LE treatment further decreased the release of interleukin 6 (IL-6) and restored triglyceride synthesis, which is the main feature of a healthy adipocyte.
Keyphrases
- insulin resistance
- adipose tissue
- glycemic control
- type diabetes
- high fat diet induced
- rheumatoid arthritis
- health promotion
- high fat diet
- oxidative stress
- metabolic syndrome
- polycystic ovary syndrome
- skeletal muscle
- cardiovascular disease
- diabetic rats
- machine learning
- essential oil
- high glucose
- endothelial cells
- human health
- weight loss
- drug induced
- fatty acid
- risk assessment
- single molecule