The Effect of Low-Dose Colchicine on the Phenotype and Function of Neutrophils and Monocytes in Patients with Chronic Coronary Artery Disease: A Double-Blind Randomized Placebo-Controlled Cross-Over Study.
Helin TercanAmber van BroekhovenHarsh BahrarTjerk OpstalBenjamin C CossinsNils RotherLaura RodwellSiroon BekkeringSaloua El MessaoudiNiels P RiksenJan-Hein CornelPublished in: Clinical pharmacology and therapeutics (2024)
Recent landmark trials showed that colchicine provides a substantial benefit in reducing major cardiovascular events in patients with coronary artery disease. Yet, its exact mechanism of action is still poorly understood. This study aimed to unravel the effect of colchicine on monocyte and neutrophil phenotype and function. A randomized double-blind placebo-controlled cross-over intervention study was executed in patients with a history of myocardial infarction. In neutrophils, colchicine treatment decreased CD62L expression and NGAL release upon ex vivo stimulation and increased PMA-induced ROS production. The effects of colchicine on monocytes were limited to a decrease in HLA-DR expression in the intermediate and nonclassical monocytes. Also, on the level of RNA expression, colchicine did not affect monocyte phenotype, while affecting various immunomodulating genes in neutrophils. Overall, our study suggests that treatment with colchicine affects neutrophil function, particularly by reducing neutrophil recruitment, lowering concentrations of NGAL, and changing the expression of various genes with immunomodulatory potential, whereas the effect on monocytes is limited.
Keyphrases
- placebo controlled
- double blind
- coronary artery disease
- poor prognosis
- cardiovascular events
- dendritic cells
- low dose
- clinical trial
- peripheral blood
- heart failure
- phase iii
- randomized controlled trial
- squamous cell carcinoma
- open label
- dna damage
- dna methylation
- cardiovascular disease
- type diabetes
- immune response
- phase ii
- genome wide
- high dose
- acute coronary syndrome
- long non coding rna
- drug induced
- risk assessment
- combination therapy
- transcatheter aortic valve replacement
- high glucose
- human health
- radiation therapy