Inhibitory effect of (-)-epigallocatechin-3-gallate and bleomycin on human pancreatic cancer MiaPaca-2 cell growth.

Sabrina BimonteMaddalena LeongitoAntonio BarbieriVitale Del VecchioMassimiliano BarbieriVittorio AlbinoMauro PiccirilloAlfonso AmoreRaimondo Di GiacomoAurelio NastoVincenza GranataAntonella PetrilloClaudio ArraFrancesco Izzo

Published in: Infectious agents and cancer (2015)

Our results indicate that EGCG and BLM have additive anti-proliferative effects in vitro by induction of apoptosis of MIA PaCa-2 cells. This combination could represent a new strategy with potential advantages for treatment of pancreatic cancer. To date, this is the first report published of the inhibitory effect of EGCG and BLM on human pancreatic cancer MIA Paca-2 cell growth.

Keyphrases

endothelial cells
cell cycle arrest
induced apoptosis
induced pluripotent stem cells
pluripotent stem cells
endoplasmic reticulum stress
cell death
oxidative stress
randomized controlled trial
systematic review
cell proliferation
signaling pathway
combination therapy