Examining Stripes on a Herd of Zebras: Impact of Genomic Matching for Ultrarare Sarcomas in Phase 1 Clinical Trials (SAMBA 102).

Justin Tyler Moyers Roberto Carmagnani Pestana Jason Roszik David S Hong Aung Naing Siqing Fu Sarina A Piha-Paul Timothy Anthony Yap Daniel D Karp Jordi Rodon Ahnert Jonathan A Livingston Maria Alejandra Zarzour Vinod Ravi Shreyaskumar R Patel Robert S Benjamin Joseph A Ludwig Cynthia E Herzog Ravin Ratan Neeta Somaiah Anthony P Conley Richard G Gorlick Funda Meric-Bernstam Vivek Subbiah

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

The results demonstrate the benefit of genomic selection in Phase 1 trials to help identify molecular subsets likely to benefit from targeted therapy.

Keyphrases

clinical trial
copy number
high grade
peripheral blood
phase ii
open label