Estimating the Effect of Early Treatment Initiation in Parkinson's Disease Using Observational Data.
Lieneke van den HeuvelLuc J W EversMarjan J MeindersBart PostAnne M StiggelboutTom M HeskesBastiaan R BloemJesse H KrijthePublished in: Movement disorders : official journal of the Movement Disorder Society (2020)
Earlier treatment initiation does not lead to worse MDS-UPDRS motor scores and may offer small improvements. These findings, based on observational data, are in line with earlier findings from clinical trials. Observational data, when combined with appropriate causal methods, are a valuable source of additional evidence to support real-world clinical decisions. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.