Improved survival of children and adolescents with classical Hodgkin lymphoma treated on a harmonised protocol in South Africa.
Jennifer Ann GeelAnel Van ZylJan du PlessisMarc Gerald HendricksYasmin GogaAmy CarrBeverley NeethlingArtsiom HramykaFareed OmarRema MathewLizette LouwThanushree NaidooThandeka NgcanaTanya SchickerlingVutshilo NetshituniElelwani MadzhiaLiezl du PlessisThomas W KelseyDaynia Elizabeth BallotMonika L MetzgerPublished in: Pediatric blood & cancer (2023)
In the first South African harmonised HL treatment protocol, risk stratification correlated with prognosis. Two-year OS of HIV-positive and HIV-negative patients improved since 2010, partially ascribed to standardised treatment and increased supportive care. This improved survival strengthens the harmonisation movement and gives hope that South Africa will achieve the WHO Global Initiative for Childhood Cancer goals.
Keyphrases
- hiv positive
- south africa
- men who have sex with men
- antiretroviral therapy
- hodgkin lymphoma
- randomized controlled trial
- human immunodeficiency virus
- newly diagnosed
- hiv infected
- hiv testing
- quality improvement
- healthcare
- childhood cancer
- ejection fraction
- hepatitis c virus
- prognostic factors
- combination therapy
- hiv aids
- pain management
- patient reported
- smoking cessation
- global health