The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling.

Inmaculada Ruz-MaldonadoBo LiuPatricio AtanesAttilio PingitoreGuo Cai HuangPratik ChoudharyShanta Jean Persaud

Published in: Cellular and molecular life sciences : CMLS (2020)

These observations may be useful in directing development of peripherally restricted novel therapeutics that are structurally related to SR141716A and AM251, and which potentiate glucose-induced insulin secretion and stimulate β-cell proliferation.

Keyphrases

cell proliferation
endothelial cells
high glucose
diabetic rats
induced pluripotent stem cells
drug induced
small molecule
pluripotent stem cells
fatty acid
type diabetes
blood pressure
pi k akt
signaling pathway
skeletal muscle
adipose tissue