Radiation Therapy With or Without Cisplatin for Local Recurrences of Endometrial Cancer: Results From an NRG Oncology/GOG Prospective Randomized Multicenter Clinical Trial.
Ann H KloppDanielle EnserroMatthew A PowellMarcus RandallJulian C SchinkRobert S MannelLaura HolmanDavid BenderChristina L KushnirFloor J BackesSusan L ZweizigSteven WaggonerKristin A BradleyLana DeSouza LawrenceParviz HanjaniChristopher J DarusWilliam SmallHiginia R CardenesJonathan M FeddockDavid Scott MillerPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2024)
Excellent outcomes can be achieved for women with localized recurrences of endometrial cancer when treated with radiation therapy. The addition of chemotherapy does not improve PFS for patients treated with definitive radiation therapy for recurrent endometrial cancer and increases acute toxicity. Patients with low-grade and vaginal recurrences who constituted the majority of those enrolled are best treated with radiation therapy alone.
Keyphrases
- endometrial cancer
- radiation therapy
- low grade
- locally advanced
- double blind
- clinical trial
- high grade
- open label
- radiation induced
- placebo controlled
- phase ii
- phase iii
- liver failure
- palliative care
- rectal cancer
- oxidative stress
- squamous cell carcinoma
- study protocol
- drug induced
- randomized controlled trial
- cross sectional
- metabolic syndrome
- aortic dissection
- newly diagnosed
- hepatitis b virus
- insulin resistance
- acute respiratory distress syndrome
- weight loss
- chemotherapy induced