Retrograde interferon-gamma signaling induces major histocompatibility class I expression in human-induced pluripotent stem cell-derived neurons.
Benjamin D S ClarksonMisha S PatelReghann G LaFrance-CoreyCharles L HowePublished in: Annals of clinical and translational neurology (2017)
These results provide conclusive evidence that human axons are competent to express MHC class I molecules, suggesting that inflammatory factors enriched in demyelinated lesions may render axons vulnerable to attack by autoreactive CD8+ T cells in patients with MS. Future work will be aimed at identifying pathogenic anti-axonal T cells in these patients.
Keyphrases
- endothelial cells
- end stage renal disease
- high glucose
- induced pluripotent stem cells
- poor prognosis
- ejection fraction
- pluripotent stem cells
- multiple sclerosis
- mass spectrometry
- spinal cord injury
- oxidative stress
- prognostic factors
- spinal cord
- ms ms
- peritoneal dialysis
- diabetic rats
- patient reported outcomes
- binding protein
- optical coherence tomography