Use of amnion-derived cellular cytokine solution for the treatment of gingivitis: A 2-week safety, dose-ranging, proof-of-principle randomized trial.

Hatice HasturkDavid SteedEmre TosunMelissa MartinsConstantinos FlorosDaniel NguyenDanielle StephensMaryann CuginiJacqueline StarrThomas E Van Dyke

Published in: Journal of periodontology (2021)

In this "first in human oral cavity" study, topical ST266 was safe and effective in reducing gingival inflammation in 6 weeks. Longitudinal studies with large sample sizes are warranted to assess the therapeutic value of this novel host modulatory compound in the treatment of periodontal diseases.

Keyphrases

endothelial cells
randomized controlled trial
clinical trial
cross sectional
combination therapy
study protocol