Based on Network Pharmacology and RNA Sequencing Techniques to Explore the Molecular Mechanism of Huatan Jiangzhuo Decoction for Treating Hyperlipidemia.

Xiaowen Zhou Zhenqian Yan Yaxin Wang Qi Ren Xiaoqi Liu Ge Fang Bin Wang Xian-Tao Li

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

In brief, network pharmacology predicted that HTJZD exerts a therapeutic effect on hyperlipidemia. The animal experimental results confirmed that HTJZD suppressed the pathological process induced by hyperlipidemia by regulating the expression of targets involved in lipid metabolism and insulin resistance.

Keyphrases

high fat diet
insulin resistance
high fat diet induced
adipose tissue
poor prognosis
single cell
metabolic syndrome
type diabetes
polycystic ovary syndrome
skeletal muscle
fatty acid
weight loss