Recent advances in nanoformulation-based delivery for cancer immunotherapy.
Seyedeh Saimeh BokhariTayyab AliMuhammad NaeemFatma HussainAbdul NasirPublished in: Nanomedicine (London, England) (2024)
Cancer is one of the leading causes of mortality worldwide, and its treatment faces several challenges. Phytoconstituents derived from recently discovered medicinal plants through nanotechnology potentially target cancer cells via PI3K/Akt/mTOR pathways and exert their effects selectively through the generation of reactive oxygen species through β-catenin inhibition, DNA damage, and increasing caspase 3/9 and p53 expression. These nanocarriers act specifically against different cancer cell lines such as HT-29, MOLT-4 human leukemia cancer and MCF-7 cell lines SKOV-3, Caov-3, SW-626, HepG2, A-549, HeLa, and MCF-7. This review comprehensively elaborates on the cellular and molecular mechanisms, and therapeutic prospects of various plant-mediated nanoformulations to attain a revolutionary shift in cancer immunotherapy.
Keyphrases
- papillary thyroid
- dna damage
- squamous cell
- reactive oxygen species
- endothelial cells
- drug delivery
- breast cancer cells
- cell proliferation
- bone marrow
- poor prognosis
- lymph node metastasis
- type diabetes
- cell death
- squamous cell carcinoma
- risk factors
- induced pluripotent stem cells
- signaling pathway
- pluripotent stem cells