Longitudinal Pharmacokinetic-Pharmacodynamic Biomarkers Correlate With Treatment Outcome in Drug-Sensitive Pulmonary Tuberculosis: A Population Pharmacokinetic-Pharmacodynamic Analysis.

Frank KloproggeHenry C MwandumbaGertrude BandaMercy KamdoloziDoris ShaniElizabeth L CorbettNadia KontogianniSteve WardSaye H KhooGeraint R DaviesDerek J Sloan

Published in: Open forum infectious diseases (2020)

Patterns of early bacillary clearance matter. Static measurements such as month 2 sputum conversion and pharmacokinetic parameters such as C MAX/MIC and AUC0-24/MIC were predictive of treatment failure, but modeling of quantitative longitudinal data was required to assess the risk of recurrence. Pooled individual patient data analyses from larger datasets are needed to confirm these findings.

Keyphrases

pulmonary tuberculosis
mycobacterium tuberculosis
electronic health record
big data
cross sectional
case report
high resolution
emergency department
randomized controlled trial
combination therapy
study protocol
adverse drug
phase iii