Development and Validation of a Predictive Model for Toxicity of Neoadjuvant Chemoradiotherapy in Rectal Cancer in the CAO/ARO/AIO-04 Phase III Trial.
Markus DiefenhardtDaniel MartinEthan Bernard LudmirMaximilian FleischmannRalf-Dieter HofheinzMichael GhadimiRebekka KosmalaBülent PolatTim FriedeBruce D MinskyClaus RödelEmmanouil FokasPublished in: Cancers (2022)
We developed and validated a predictive model for toxicity using gender, BMI, and emotional functioning. Such a model could help identify patients at risk for treatment-related high-grade toxicity to assist in treatment guidance and patient participation in shared decision making.
Keyphrases
- rectal cancer
- phase iii
- locally advanced
- high grade
- clinical trial
- oxidative stress
- open label
- end stage renal disease
- ejection fraction
- newly diagnosed
- mental health
- low grade
- lymph node
- randomized controlled trial
- squamous cell carcinoma
- combination therapy
- placebo controlled
- weight gain
- replacement therapy
- smoking cessation
- drug induced