SRI-30827, a novel allosteric modulator of the dopamine transporter, alleviates HIV-1 Tat-induced potentiation of cocaine conditioned place preference in mice.
Haylee R HammondShainnel O EansThomas J CirinoSubramaniam AnanthanAna Catya Jimenez-TorresJun ZhuJay P McLaughlinPublished in: NeuroImmune pharmacology and therapeutics (2023)
These findings add to a growing body of evidence that allosteric modulation of DAT could provide a promising therapeutic intervention for patients with comorbid HIV-1 and cocaine use disorder (CUD).
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv testing
- hiv infected
- human immunodeficiency virus
- small molecule
- hepatitis c virus
- hiv aids
- men who have sex with men
- randomized controlled trial
- prefrontal cortex
- high glucose
- south africa
- diabetic rats
- mouse model
- uric acid
- drug induced
- endothelial cells
- adipose tissue
- wild type