Jay P McLaughlin (Jay McLaughlin)

ORCID

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 37

Top Venues

Molecules (Basel, Switzerland)

Nature

NeuroImmune pharmacology and therapeutics

Research square

University of Florida

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Florida

United States

Associate Professor :: Pharmacodynamics

Publications

Evan S O'Brien, Vipin Ashok Rangari, Amal El Daibani, Shainnel O Eans, Haylee R Hammond, Elizabeth White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Qianru Jiang, Kevin Appourchaux, Weijiao Huang, Chensong Zhang, Brandon J Kennedy, Jesper M Mathiesen, Tao Che, Jay P McLaughlin, Susruta Majumdar, Brian K Kobilka
A µ-opioid receptor modulator that works cooperatively with naloxone. Nature 631 (8021) (2024)
Evan S O'Brien, Vipin Ashok Rangari, Amal El Daibani, Shainnel O Eans, Haylee R Hammond, Elizabeth White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Qianru Jiang, Kevin Appourchaux, Weijiao Huang, Chensong Zhang, Brandon J Kennedy, Jesper M Mathiesen, Tao Che, Jay P McLaughlin, Susruta Majumdar, Brian K Kobilka
A µ-opioid receptor modulator that works cooperatively with naloxone. Nature 631 (8021) (2024)
Evan S O'Brien, Vipin Ashok Rangari, Amal El Daibani, Shainnel O Eans, Haylee R Hammond, Elizabeth White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Qianru Jiang, Kevin Appourchaux, Weijiao Huang, Chensong Zhang, Brandon J Kennedy, Jesper M Mathiesen, Tao Che, Jay P McLaughlin, Susruta Majumdar, Brian K Kobilka
A µ-opioid receptor modulator that works cooperatively with naloxone. Nature (2024)
Tao Che, Balazs Varga, Sarah M Bernhard, Amal El Daibani, Saheem Zaidi, Jordy Homing Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina Nazarova, Alexa Kouvelis, Shainnel Eans, Elyssa B Margolis, Jonathan F Fay, Amynah Amir Ali Pradhan, Vsevolod Katritch, Jay P McLaughlin, Susruta Majumdar
Structure-Guided Design of Partial Agonists at an Opioid Receptor. Research square (2024)
Tao Che, Balazs Varga, Sarah M Bernhard, Amal El Daibani, Saheem Zaidi, Jordy Homing Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina Nazarova, Alexa Kouvelis, Shainnel Eans, Elyssa B Margolis, Jonathan F Fay, Amynah Amir Ali Pradhan, Vsevolod Katritch, Jay P McLaughlin, Susruta Majumdar
Structure-Guided Design of Partial Agonists at an Opioid Receptor. Research square (2024)
Tao Che, Balazs Varga, Sarah M Bernhard, Amal El Daibani, Saheem Zaidi, Jordy Homing Lam, Jhoan Aguilar, Kevin Appourchaux, Antonina Nazarova, Alexa Kouvelis, Shainnel Eans, Elyssa B Margolis, Jonathan F Fay, Amynah Amir Ali Pradhan, Vsevolod Katritch, Jay P McLaughlin, Susruta Majumdar
Structure-Guided Design of Partial Agonists at an Opioid Receptor. Research square (2024)
Evan S O'Brien, Vipin Ashok Rangari, Amal El Daibani, Shainnel O Eans, Haylee R Hammond, Elizabeth White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Qianru Jiang, Kevin Appourchaux, Weijiao Huang, Chensong Zhang, Brandon J Kennedy, Jesper M Mathiesen, Tao Che, Jay P McLaughlin, Susruta Majumdar, Brian K Kobilka
A µ-opioid receptor modulator that works cooperatively with naloxone. Nature (2024)
Evan S O'Brien, Vipin Ashok Rangari, Amal El Daibani, Shainnel O Eans, Haylee R Hammond, Elizabeth White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Qianru Jiang, Kevin Appourchaux, Weijiao Huang, Chensong Zhang, Brandon J Kennedy, Jesper M Mathiesen, Tao Che, Jay P McLaughlin, Susruta Majumdar, Brian K Kobilka
A µ-opioid receptor modulator that works cooperatively with naloxone. Nature 631 (8021) (2024)
Evan S O'Brien, Vipin Ashok Rangari, Amal El Daibani, Shainnel O Eans, Haylee R Hammond, Elizabeth White, Haoqing Wang, Yuki Shiimura, Kaavya Krishna Kumar, Qianru Jiang, Kevin Appourchaux, Weijiao Huang, Chensong Zhang, Brandon J Kennedy, Jesper M Mathiesen, Tao Che, Jay P McLaughlin, Susruta Majumdar, Brian K Kobilka
A µ-opioid receptor modulator that works cooperatively with naloxone. Nature 631 (8021) (2024)
Ramanjaneyulu Rayala, Annika Tiller, Shahayra A Majumder, Heather M Stacy, Shainnel O Eans, Aleksandra Nedovic, Jay P McLaughlin, Predrag Cudic
Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration. Molecules (Basel, Switzerland) 28 (4) (2023)
Kristen H Scherrer, Shainnel O Eans, Jessica M Medina, Sanjeewa N Senadheera, Tanvir Khaliq, Thomas F Murray, Jay P McLaughlin, Jane V Aldrich
Tryptophan Substitution in CJ-15,208 ( cyclo [Phe-D-Pro-Phe-Trp]) Introduces δ-Opioid Receptor Antagonism, Preventing Antinociceptive Tolerance and Stress-Induced Reinstatement of Extinguished Cocaine-Conditioned Place Preference. Pharmaceuticals (Basel, Switzerland) 16 (9) (2023)
Ramanjaneyulu Rayala, Annika Tiller, Shahayra A Majumder, Heather M Stacy, Shainnel O Eans, Aleksandra Nedovic, Jay P McLaughlin, Predrag Cudic
Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration. Molecules (Basel, Switzerland) 28 (4) (2023)
Haylee R Hammond, Shainnel O Eans, Thomas J Cirino, Subramaniam Ananthan, Ana Catya Jimenez-Torres, Jun Zhu, Jay P McLaughlin
SRI-30827, a novel allosteric modulator of the dopamine transporter, alleviates HIV-1 Tat-induced potentiation of cocaine conditioned place preference in mice. NeuroImmune pharmacology and therapeutics 3 (1) (2023)
Ramanjaneyulu Rayala, Annika Tiller, Shahayra A Majumder, Heather M Stacy, Shainnel O Eans, Aleksandra Nedovic, Jay P McLaughlin, Predrag Cudic
Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration. Molecules (Basel, Switzerland) 28 (4) (2023)
Ramanjaneyulu Rayala, Annika Tiller, Shahayra A Majumder, Heather M Stacy, Shainnel O Eans, Aleksandra Nedovic, Jay P McLaughlin, Predrag Cudic
Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration. Molecules (Basel, Switzerland) 28 (4) (2023)
Ramanjaneyulu Rayala, Annika Tiller, Shahayra A Majumder, Heather M Stacy, Shainnel O Eans, Aleksandra Nedovic, Jay P McLaughlin, Predrag Cudic
Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration. Molecules (Basel, Switzerland) 28 (4) (2023)
Ramanjaneyulu Rayala, Annika Tiller, Shahayra A Majumder, Heather M Stacy, Shainnel O Eans, Aleksandra Nedovic, Jay P McLaughlin, Predrag Cudic
Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration. Molecules (Basel, Switzerland) 28 (4) (2023)
Haylee R Hammond, Shainnel O Eans, Thomas J Cirino, Subramaniam Ananthan, Ana Catya Jimenez-Torres, Jun Zhu, Jay P McLaughlin
SRI-30827, a novel allosteric modulator of the dopamine transporter, alleviates HIV-1 Tat-induced potentiation of cocaine conditioned place preference in mice. NeuroImmune pharmacology and therapeutics 3 (1) (2023)
Haylee R Hammond, Shainnel O Eans, Thomas J Cirino, Subramaniam Ananthan, Ana Catya Jimenez-Torres, Jun Zhu, Jay P McLaughlin
SRI-30827, a novel allosteric modulator of the dopamine transporter, alleviates HIV-1 Tat-induced potentiation of cocaine conditioned place preference in mice. NeuroImmune pharmacology and therapeutics 3 (1) (2023)
Yangmei Li, Shainnel O Eans, Michelle L Ganno, Abbe Eliasof, Richard A Houghten, Jay P McLaughlin
Identification and Pharmacological Characterization of a Low-Liability Antinociceptive Bifunctional MOR/DOR Cyclic Peptide. Molecules (Basel, Switzerland) 28 (22) (2023)
Lisa L Wilson, Amy R Alleyne, Shainnel O Eans, Thomas J Cirino, Heather M Stacy, Marco Mottinelli, Sebastiano Intagliata, Christopher R McCurdy, Jay P McLaughlin
Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain. Molecules (Basel, Switzerland) 27 (11) (2022)
Abdelfattah Faouzi, Haoqing Wang, Saheem A Zaidi, Jeffrey F DiBerto, Tao Che, Qianhui Qu, Michael J Robertson, Manish K Madasu, Amal El Daibani, Balazs R Varga, Tiffany Zhang, Claudia Ruiz, Shan Liu, Jin Xu, Kevin Appourchaux, Samuel T Slocum, Shainnel O Eans, Michael D Cameron, Ream Al-Hasani, Ying Xian Pan, Bryan L Roth, Jay P McLaughlin, Georgios Skiniotis, Vsevolod Katritch, Brian K Kobilka, Susruta Majumdar
Structure-based design of bitopic ligands for the µ-opioid receptor. Nature (2022)
Mayur A Doke, Jay P McLaughlin, Hamid Baniasadi, Thangavel Samikkannu
Sleep Disorder and Cocaine Abuse Impact Purine and Pyrimidine Nucleotide Metabolic Signatures. Metabolites 12 (9) (2022)
Jay P McLaughlin, Ramanjaneyulu Rayala, Ashley J Bunnell, Mukund P Tantak, Shainnel O Eans, Khadija Nefzi, Michelle L Ganno, Colette T Dooley, Adel Nefzi
Bis-Cyclic Guanidine Heterocyclic Peptidomimetics as Opioid Ligands with Mixed μ-, κ- and δ-Opioid Receptor Interactions: A Potential Approach to Novel Analgesics. International journal of molecular sciences 23 (17) (2022)
Gordana D Vitaliano, Jae K Kim, Marc J Kaufman, Christopher W Adam, Gonzalo Zeballos, Abinaya Shanmugavadivu, Sivan Subburaju, Jay P McLaughlin, Scott E Lukas, Franco Vitaliano
Clathrin-nanoparticles deliver BDNF to hippocampus and enhance neurogenesis, synaptogenesis and cognition in HIV/neuroAIDS mouse model. Communications biology 5 (1) (2022)
Lisa L Wilson, Shainnel O Eans, Insitar Ramadan-Siraj, Maria N Modica, Giuseppe Romeo, Sebastiano Intagliata, Jay P McLaughlin
Examination of the Novel Sigma-1 Receptor Antagonist, SI 1/28, for Antinociceptive and Anti-allodynic Efficacy against Multiple Types of Nociception with Fewer Liabilities of Use. International journal of molecular sciences 23 (2) (2022)
Thomas J Cirino, Amy R Alleyne, Vinicius Duarte, Ariana Figueroa, Chloe A Simons, Emet M Anceaume, Justin Kendrick, Olivia Wallman, Shainnel O Eans, Heather M Stacy, Jessica M Medina, Jay P McLaughlin
Expression of Human Immunodeficiency Virus Transactivator of Transcription (HIV-Tat1-86) Protein Alters Nociceptive Processing that is Sensitive to Anti-Oxidant and Anti-Inflammatory Interventions. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2021)
Soumen Chakraborty, Jeffrey F DiBerto, Abdelfattah Faouzi, Sarah M Bernhard, Anna M Gutridge, Steven Ramsey, Yuchen Zhou, Davide Provasi, Nitin Nuthikattu, Rahul Jilakara, Melissa N F Nelson, Wesley B Asher, Shainnel O Eans, Lisa L Wilson, Satyanarayana M Chintala, Marta Filizola, Richard M Van Rijn, Elyssa B Margolis, Bryan L Roth, Jay P McLaughlin, Tao Che, Dalibor Sames, Jonathan A Javitch, Susruta Majumdar
A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects. Journal of medicinal chemistry 64 (18) (2021)
Soumen Chakraborty, Rajendra Uprety, Amal E Daibani, Valerie L Rouzic, Amanda Hunkele, Kevin Appourchaux, Shainnel O Eans, Nitin Nuthikattu, Rahul Jilakara, Lisa Thammavong, Gavril W Pasternak, Ying-Xian Pan, Jay P McLaughlin, Tao Che, Susruta Majumdar
Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom. ACS chemical neuroscience 12 (14) (2021)
Ram Kandasamy, Todd M Hillhouse, Kathryn E Livingston, Kelsey E Kochan, Claire Meurice, Shainnel O Eans, Ming-Hua Li, Andrew D White, Bernard P Roques, Jay P McLaughlin, Susan L Ingram, Neil T Burford, Andrew Alt, John R Traynor
Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects. Proceedings of the National Academy of Sciences of the United States of America 118 (16) (2021)
Jason J Paris, Xi Chen, Joseph Anderson, Alaa N Qrareya, Fakhri Mahdi, Fei Du, Jay P McLaughlin, Marc J Kaufman
In vivo proton magnetic resonance spectroscopy detection of metabolite abnormalities in aged Tat-transgenic mouse brain. GeroScience 43 (4) (2021)
Lisa L Wilson, Soumen Chakraborty, Shainnel O Eans, Thomas J Cirino, Heather M Stacy, Chloe A Simons, Rajendra Uprety, Susruta Majumdar, Jay P McLaughlin
Kratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal. Cellular and molecular neurobiology 41 (5) (2021)
Soumen Chakraborty, Rajendra Uprety, Samuel T Slocum, Takeshi Irie, Valerie Le Rouzic, Xiaohai Li, Lisa L Wilson, Brittany Scouller, Amy F Alder, Andrew C Kruegel, Michael Ansonoff, Andras Varadi, Shainnel O Eans, Amanda Hunkele, Abdullah Allaoa, Sanjay Kalra, Jin Xu, Ying Xian Pan, John Pintar, Bronwyn M Kivell, Gavril W Pasternak, Michael D Cameron, Jay P McLaughlin, Dalibor Sames, Susruta Majumdar
Oxidative Metabolism as a Modulator of Kratom's Biological Actions. Journal of medicinal chemistry 64 (22) (2021)
Ariana C Brice-Tutt, Sanjeewa N Senadheera, Michelle L Ganno, Shainnel O Eans, Tanvir Khaliq, Thomas F Murray, Jay P McLaughlin, Jane V Aldrich
Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles. Molecules (Basel, Switzerland) 25 (17) (2020)
Mayur Doke, Venkatesh Jeganathan, Jay P McLaughlin, Thangavel Samikkannu
HIV-1 Tat and cocaine impact mitochondrial epigenetics: effects on DNA methylation. Epigenetics 16 (9) (2020)
Ariana C Brice-Tutt, Lisa L Wilson, Shainnel O Eans, Heather M Stacy, Chloe A Simons, Grant G Simpson, Jeremy S Coleman, Michael J Ferracane, Jane V Aldrich, Jay P McLaughlin
Multifunctional opioid receptor agonism and antagonism by a novel macrocyclic tetrapeptide prevents reinstatement of morphine-seeking behaviour. British journal of pharmacology 177 (18) (2020)
Thomas J Cirino, Scott W Harden, Jay P McLaughlin, Charles J Frazier
Region-specific effects of HIV-1 Tat on intrinsic electrophysiological properties of pyramidal neurons in mouse prefrontal cortex and hippocampus. Journal of neurophysiology 123 (4) (2020)

Jay P McLaughlin.css-eqlu8i{font-size:small;padding-left:4px;} (Jay McLaughlin)

Publication Activity (10 Years)

Top Topics

Top Venues

Jay P McLaughlin (Jay McLaughlin)