Image-Based Dosimetry in Dogs and Cross-Reactivity with Human Tissues of IGF2R-Targeting Human Antibody.
Kevin J H AllenOhyun KwonMatthew R HutchesonJoseph J GrudzinskiStuart M CainFrederic A CruzRemitha M VinayakamoorthyYing S SunLindsay FairleyChandra B PrabaharanRyan DickinsonValerie MacDonald-DickinsonMaruti UppalapatiBryan P BednarzEkaterina DadachovaPublished in: Pharmaceuticals (Basel, Switzerland) (2023)
Image-based dosimetry has defined a safe therapeutic range for canine clinical trials, while immunohistochemistry has suggested that the antibody will not cross-react with healthy human tissues.