Synonymous polymorphism rs201256011 in dopamine receptor type 2 gene is associated with schizophrenia and PANSS score in Pakistani population: A first report.

Qurat-Ul-Ain AmirFarina HanifWashdev WashdevFareena BilwaniShabana Usman Simjee

Published in: International journal of clinical practice (2020)

In conclusion, genetic variants rs1801028 and rs6277 of DRD2 are not associated with schizophrenia in Pakistani population. While, previously unreported polymorphism rs201256011 have shown significant association with schizophrenia and its severity. A large scale multicentre replication study is required to confirm the association of this SNP with schizophrenia.

Keyphrases

bipolar disorder
genome wide
clinical trial
randomized controlled trial
study protocol
metabolic syndrome
gene expression
cross sectional
dna methylation
transcription factor
double blind