Herbal Tea Essences (HTE) Ameliorate HFD-Induced Obesity.
Yue WangYing HanRongfu LvChengyong HeZhenghong ZuoYing ChenJiyi HuangPublished in: Evidence-based complementary and alternative medicine : eCAM (2022)
Tea is one of the most popular beverages in the world. The health-promoting effects of tea and its individual constituents, including antiobesity and antihyperlipidaemia effects, have been well accepted. In this study, we evaluated the effects of herbal tea essence (HTE), a commercial product extracted from black tea, on HFD-induced obesity in mice. HTE effectively reduces the gain in body weight and improves glucose tolerance and insulin sensitivity after HFD treatment. HTE inhibits lipid accumulation in the body and reduces serum lipid contents. Furthermore, HTE negatively regulates the expression levels of genes that control lipogenesis and gluconeogenesis and upregulates the expression of genes for lipid β oxidation. The regulatory effects of HTE on these genes may occur through activation of the AKT, IRS-1, and AMPK signalling pathways. Our observations suggest that HTE could be a promising option for nutritional intervention in the treatment of obesity.
Keyphrases
- high fat diet induced
- insulin resistance
- high fat diet
- metabolic syndrome
- body weight
- weight loss
- type diabetes
- poor prognosis
- genome wide
- weight gain
- public health
- randomized controlled trial
- high glucose
- healthcare
- skeletal muscle
- signaling pathway
- bioinformatics analysis
- risk assessment
- drug induced
- gene expression
- cell proliferation
- transcription factor
- binding protein
- dna methylation
- body mass index
- social media
- replacement therapy