Different systemic rheumatic diseases as risk factors for COVID-19-related mortality.
George E FragoulisVassiliki-Kalliopi BourniaPetros P SfikakisPublished in: Clinical rheumatology (2022)
COVID-19 has been associated with increased morbidity and mortality, globally. Whether COVID-19-related mortality is increased in patients with systemic rheumatic diseases (SRDs) is still debatable. Although results are somewhat conflicting, there are a handful of nationwide studies published indicating that, in individuals with SRD, there is signal for increased adverse COVID-19-related outcomes and higher mortality. It appears that there are differences in COVID-19-related mortality across various SRDs. Besides, certain disease-specific (disease activity, disease duration, medication received) and/or other features (e.g. comorbidities) seem to also affect COVID-19-related mortality in SRD patients. Herein, we wanted to highlight that a more individualized approach taking into consideration the effect of the aforementioned factors into the risk calculation for COVID-19 adverse outcomes, including mortality, in SRD patients is warranted. A multinational study based on nationwide data, examining all common SRDs and stratifying accordingly, would be of interest, toward this direction. Key Points • It is still debatable whether Covid-19-related mortality is increased in patients with sytemic rheumatic diseases (SRD). • Disease-specific risk factors (e.g. type of SRD, disease activity) should be taken into account in risk assessment for Covid-19-releted outcomes in SRD patients.
Keyphrases
- coronavirus disease
- sars cov
- risk factors
- disease activity
- end stage renal disease
- cardiovascular events
- systemic lupus erythematosus
- ejection fraction
- rheumatoid arthritis
- risk assessment
- newly diagnosed
- chronic kidney disease
- healthcare
- peritoneal dialysis
- type diabetes
- prognostic factors
- randomized controlled trial
- ankylosing spondylitis
- rheumatoid arthritis patients
- metabolic syndrome
- adipose tissue
- patient reported outcomes
- insulin resistance
- heavy metals
- artificial intelligence
- human health
- meta analyses