Associations of genetically predicted fatty acid levels across the phenome: A mendelian randomisation study.
Loukas ZagkosMarie-Joe DibRui C PintoDipender GillFotios KoskeridisFotios DrenosGeorgios MarkozannesPaul ElliottVerena ZuberKostas TsilidisAbbas DehghanJoanna TzoulakiPublished in: PLoS medicine (2022)
Our study suggests potentially protective effects of circulating DHA and omega-3 concentrations on cholelithiasis and cholecystitis and on obesity, highlighting the need to further assess them as prevention treatments in clinical trials. Moreover, our findings do not support the supplementation of unsaturated fatty acids for cardiovascular disease prevention.