PUFA ω-3 and ω-6 biomarkers and sleep: a pooled analysis of cohort studies on behalf of the Fatty Acids and Outcomes Research Consortium (FORCE).
Rachel A MurphyNathan TintleWilliam S HarrisMaryam DarvishianMatti MarklundJyrki K VirtanenSari HantunenVanessa D de MelloJaakko TuomilehtoJaana LindströmMatthew A BoltIngeborg A BrouwerAlexis C WoodMackenzie SennSusan RedlineMichael Y TsaiVilmundur GudnasonGudny EiriksdottirEva LindbergAladdin H ShadyabBuyun LiuMercedes CarnethonMatti UusitupaLuc DjousseUlf RisérusLars LindRob M van DamWoon Puay KohPeilin ShiDavid SiscovickRozenn N LemaitreDariush MozaffarianPublished in: The American journal of clinical nutrition (2022)
Participants with higher concentrations of very long-chain n-3 PUFAs were less likely to have long sleep duration. While objective biomarkers reduce recall bias and misclassification, the cross-sectional design limits assessment of the temporal nature of this relation. These novel findings across 12 cohorts highlight the need for experimental and biological assessments of very long-chain n-3 PUFAs and sleep duration.