Chitosan Oligosaccharides Alleviate Heat-Stress-Induced Lipid Metabolism Disorders by Suppressing the Oxidative Stress and Inflammatory Response in the Liver of Broilers.

Heat stress has been reported to induce hepatic oxidative stress and alter lipid metabolism and fat deposition in broilers. Chitosan oligosaccharides (COSs), a natural oligosaccharide, has anti-oxidant, anti-inflammatory, and lipid-lowering effects. This study is conducted to evaluate dietary COS supplementation on hepatic anti-oxidant capacity, inflammatory response, and lipid metabolism in heat-stressed broilers. The results indicate that heat-stress-induced poor ( p < 0.05) growth performance and higher ( p < 0.05) abdominal adiposity are alleviated by COS supplementation. Heat stress increases ( p < 0.05) serum AST and ATL activity, serum and liver MDA, TG, TC, and LDL-C levels, and the expression of hepatic IL-1β , IL-6 , SREBP-1c , ACC , and FAS , while it decreases ( p < 0.05) serum SOD and CAT activity, liver GSH-Px and SOD activity, and the expression of hepatic Nrf2 , GPX1 , IL-10 , MTTP , PPARα , and CPT1. Nevertheless, COS supplementation decreases ( p < 0.05) serum AST and ATL activity, serum and liver MDA, TG, TC, and LDL-C levels, and the expression of hepatic IL-1β , IL-6 , SREBP-1c , ACC , and FAS , while it increases ( p < 0.05) serum SOD and CAT activity, liver GSH-Px activity, and the expression of hepatic Nrf2 , CAT , IL-10 , LPL , MTTP , PPARα , and CPT1. In conclusion, COS could alleviate heat-stress-induced lipid metabolism disorders by enhancing hepatic anti-oxidant and anti-inflammatory capacity.