STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation.
Hannah M GordonNeil MajithiaPatrick E MacDonaldJocelyn E Manning FoxPoonam R SharmaFrances L ByrneKyle L HoehnCarmella Evans-MolinaLinda LangmanKenneth L BraymanCraig S NunemakerPublished in: Endocrine (2017)
These findings suggest that increased STEAP4 mRNA expression is associated with inflammatory stimuli, whereas lower STEAP4 expression is associated with obesity in human islets. Given its putative protective role, downregulation of STEAP4 by chronic obesity suggests a mechanism for reduced islet protection against cellular damage.
Keyphrases
- endothelial cells
- body mass index
- oxidative stress
- poor prognosis
- weight gain
- metabolic syndrome
- insulin resistance
- weight loss
- type diabetes
- induced pluripotent stem cells
- high fat diet induced
- pluripotent stem cells
- cell proliferation
- binding protein
- physical activity
- signaling pathway
- long non coding rna
- adipose tissue
- skeletal muscle