Blockade of histamine receptor H1 augments immune checkpoint therapy by enhancing MHC-I expression in pancreatic cancer cells.

PingShan ZhongKohei NakataKoki OyamaNobuhiro HigashijimaAkiko SagaraSatomi DateHaiZhen LuoMasataka HayashiAkihiro KuboChenYi WuShan HeTakeo YamamotoKazuhiro KoikawaChika IwamotoToshiya AbeNaoki IkenagaKenoki OhuchidaTakashi MorisakiYoshinao OdaKeiji KubaMasafumi Nakamura

Published in: Journal of experimental & clinical cancer research : CR (2024)

HRH1 plays an immunosuppressive role in cancer cells. Consequently, HRH1 intervention may be a promising method to amplify the responsiveness of PDAC to immunotherapy.

Keyphrases

poor prognosis
randomized controlled trial
binding protein
stem cells
cell therapy
chemotherapy induced