Deregulation of the imprinted DLK1-DIO3 locus ncRNAs is associated with replicative senescence of human adipose-derived stem cells.
Silvia García-LópezCarmen Albo-CastellanosRocio G UrdinguioSusana CañónFátima Sánchez-CaboAlberto Martínez-SerranoMario F FragaAntonio BernadPublished in: PloS one (2018)
A direct relationship between DLK1-DIO3 deregulation and replicative senescence of hADSCs is reported, involving upregulation of a very significant fraction of its largest miRNA cluster (14q32.31), paralleled by the progressive overexpression of the lncRNA MEG3, which plays a central role in the regulation of Dlk1/Dio3 activation status in mice.
Keyphrases
- endothelial cells
- cell proliferation
- dna damage
- multiple sclerosis
- stress induced
- poor prognosis
- long non coding rna
- high fat diet induced
- transcription factor
- signaling pathway
- type diabetes
- pluripotent stem cells
- long noncoding rna
- adipose tissue
- resting state
- high resolution
- functional connectivity
- metabolic syndrome