Zonated iron deposition in the periportal zone of the liver is associated with selectively enhanced lipid synthesis.
Qiuyuan YangYue WuWei LiuXiaojuan OuWei ZhangJianning WangYanzhong ChangFudi WangMing GaoSijin LiuPublished in: Liver international : official journal of the International Association for the Study of the Liver (2023)
In summary, our investigation unveils the crucial involvement of iron overload in fostering hepatic lipid accumulation in the periportal zone, at least partly mediated by the modulation of Pc expression. These insights offer new perspectives for understanding the pathogenesis of fatty liver diseases and their progression.